Yasemin DOĞAN, Ahmet KARAMAN, Hayrettin SAĞLAM, Bahadır ŞARLI, Ahmet Oğuz BAKTIR, Abdülsamed ERDEN, Hüseyin ARINÇ, Hatice KARAMAN

Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığında, Kardiyovasküler Riskin Öngördürücüsü Olan QT Dağılımı Artmıştır

AMAÇ: Alkole bağlı olmayan yağlı karaciğer hastalığı ile kardiyovasküler morbidite ve mortalite arasındaki ilişki hızla artmaktadır. QT dağılımı QTd ve düzeltilmiş QT dağılımı QTdz ventrikül repolarizasyonunun heterojenitesini göstermektedir. Çeşitli kardiyovasküler hastalığı olan ve olmayan gruplarda artmış QTd ve QTdz’nin artmış kardiyovasküler riski öngördüğü gösterilmiştir. Ancak kaynak araştırmamıza göre, alkole bağlı olmayan yağlı karaciğer hastalığında QTd ve QTdz incelenmemiştir. Alkole bağlı olmayan yağlı karaciğer hastalığında meydana gelen myokardiyal hasar ile repolarizasyonunun anormalliği arasında ilişki olabileceğini varsaydık.YÖNTEMLER: Gastroenteroloji polikliniğine başvurmuş ve alkole bağlı olmayan yağlı karaciğer hastalığı tespit edilmiş hastalar çalışmaya alındı.Yaş ve cinsiyet eşleşmesi yapılan sağlıklı kontrol bireyler ile QTd ve QTdz değerleri karşılaştırıldı.BULGULAR: Alkole bağlı olmayan yağlı karaciğer hastalığı tespit edilmiş hastalarda QTd 47.8±22.7 vs 22.5±7.5 ms, p

Anahtar Kelimeler:

QT dağılımı, Alkole bağlı olmayan yağlı karaciğer hastalığı, kardiyovasküler risk

QT Dispersion Which Predicts Cardiovascular Adverse Event Risk, Increases In Non Alcoholic Fatty Liver Disease

OBJECTIVE: Association of cardiovascular morbidity and mortality with non alcoholic fatty liver disease NAFLD is increasing rapidly. The QT dispersion QTd and QT corrected dispersion QTcd reflects the heterogeneity of ventricular repolarisation.Predicting cardiovascular risk of an increased QTd and QTcd has been shown in various clinical cardiovascular and non cardiovasculer groups, but has not yet been studied in NAFLD patients according to our search of literature. We hypothesised that NAFLD related heart injury may cause myocardial repolarisation abnormalities. METHODS: Forty five patients admitted to the department of gastroenterology outpatient clinic with the diagnose of NAFLD were included in this study. QT intervals were measured manually from the onset of QRS to the end of the T wave defined as a return to the T–P baseline.RESULTS: We found that QT dispersion 47.8±22.7 vs 22.5±7.5 ms, p

Keywords:

QT dispersion, non alcoholic fatty liver dısease, cardiovascular risk,

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