Ketoasidoz Tablosuyla Prezente Olan Yeni Tanı Diabetes Mellitus ve COVID-19 Birlikteliği: Olgu Sunumu.

SARS-CoV-2 virüsünün spike proteini yardımıyla tutunduğu fonksiyonel anjiyotensin dönüştürücü enzim 2 (ACE2) reseptörleri pankreas endokrin adacıklarda yoğun miktarda bulunur ve SARS-CoV-2 için giriş noktası olarak işlev görür. SARS-CoV-2’nin pankreatik adacık hücrelerine girişi ile direkt olarak beta hücre hasarı yapması ve virüsün hücre içine girişini takiben ACE2’nin ‘down’-regülasyonu sonucu artan anijotensin-2’nin insülin sekresyonunu azaltması olduğu düşünülmektedir. Bu olguda diyabet tanısı ve steroid kullanımı olmayan, ketoasidoz tablosuyla başvuran yeni tanı diabetes mellitus ve COVID-19 birlikteliği sunulmuştur.

Anahtar Kelimeler:

Diabetes Mellitus, COVID-19, Diabetik Ketoasidoz

The Association of Newly Diagnosed Diabetes Mellitus and COVID-19 Presenting with Ketoacidosis: A Case Report

Angiotensin converting enzyme 2 (ACE2) receptors, to which the SARS-CoV-2 virus attaches with the spike protein, are abundant in pancreatic endocrine islets and act as the entry point for SARS-CoV-2. It is thought that SARS-CoV-2 causes beta cell damage directly with its entry into pancreatic islet cells and angiotensin-2, which increases as a result of down-regulation of ACE2 following the entry of the virus into the cell, reduces insulin secretion. In this article, the association of newly diagnosed diabetes mellitus and COVID-19 presenting with ketoacidosis, without previous diagnosis of diabetes and steroid use, is presented.

Keywords:

Diabetes Mellitus, COVID-19, Diabetic Ketoacidosis,

PDF

___

Marazuela M, Giustina A, Puig-Domingo M. Endocrine and metabolic aspects of the COVID-19 pandemic [published online ahead of print, 2020 Jul 9]. Rev Endocr Metab Disord. 2020;1-13. doi:10.1007/s11154-020-09569-2
Yang JK, Lin SS, Ji XJ, Guo LM. Binding of SARS corona virus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2009;47(3):193-9.
Cuschieri S, Grech S. COVID-19 and diabetes: The why, the what and the how. J Diabetes Complications. 2020;107637
Guo W, Li M, Dong Y, et al. Diabetes is a risk fact or for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020;e3319.
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395(10229):1054e62.
Li J, Wang X, Chen J, Zuo X, Zhang H, Deng A. COVID-19 infection may cause ketosis and ketoacidosis [published online ahead of print, 2020 Apr 20]. Diabetes Obes Metab. 2020;10.1111/dom.14057. doi:10.1111/dom.14057
Kornum J.B, Thomsen R.W, Riis A, Lervang H.H, Schonheyder H.C, Sorensen H.T. Type 2 diabetes and pneumonia outcomes: A population-based cohort study. Diabetes Care. 2007;30(9):2251-7.
Yang J.K, Lin S.S, Ji X.J, Guo L.M. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2009;47(3):193-9.
Bornstein S.R, Dalan R, Hopkins D, Mingrone G, Boehm B.O. Endocrine and metabolic link to coronavirus infection. Nat Rev Endocrinol. 2020;16(6):297‐8.