Özge ÇAĞLAR, Aytaç KILIÇ, Oğuz GÜÇLÜ, Ceren CANBEY GÖRET, Fevzi Sefa DEREKÖY

Castleman Hastalığı; Boyun Kitlelerinin Nadir Nedeni

Castleman hastalığı, lenfoproliferatif hastalıkların heterojen bir grubu olup tek bir hastalık olarak düşünülmemelidir. Bu hastalık çeşitli klinik şekillerde ortaya çıkmaktadır. Üç histolojik çesidi olan hastalığın etyopatogenezinde IL-6, HİV ve HHV- 8 yer almaktadır. Bu hastalığı anlamada önemli yollar kat etmiş ve tedavi tecrübelerimiz rituximab, tokilizumab ve siltuximab gibi ilaçlarla artmış olsa da, halen etyolojisi, prognozu ve tedavisi hakkında cevapsız sorular bulunmaktadır. Aşağıdaki olgumuzda, meduller tiroid kanser tanısı ile takipte olan hasta boyunda kitle nedeni ile tarafımıza başvurmuş, boyun diseksiyonu sonrası patoloji sonucu castleman hastalığı olarak rapor edilmiştir.

Anahtar Kelimeler:

Castleman Hastalığı, Lenf Nodu, Boyun Kitlesi

Castleman Disease; A Rare Mass of Neck

Castleman disease is a heterogeneous group of non clonal lymphoproliferative disorders, so it should not be considered as a single disease. This disease has a wide spectrum of clinical expressions. Three histological types have been reported. IL-6, HIV and HHV-8 are involved in the etiopathogenesis of Castleman disease. Despite recent significant advances in our understanding of this disease and the increasing therapeutic experience with rituximab, tocilizumab and siltuximab, there are still difficult questions concerning its etiology, prognosis and optimal treatment. In this paper, follow up patient with medullary thyroid cancer was admitted because of mass in the neck and neck dissection was performed, pathology result was reported as Castleman disease.

Keywords:

Castleman Disease, Lymph nodes, Neck Mass,

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