RUTİN SAĞLIK TARAMASI YAPILAN BİREYLERDE VİTAMİN D DÜZEYLERİ

DOI: 10.26650/IUITFD.391192Amaç: D vitamini eksikliği dünya genelindeki gibi Türkiye’de de önemli halk sağlığı sorunlarındandır ve literatürde özellikle yaşlı popülasyonda osteoporoz, düşme riski ve kırıklar gibi birçok morbidite ile ilişkili olduğunu gösteren veriler mevcuttur. Gereç ve Yöntem: 2013-2016 yılları arasında rutin sağlık taraması amacıyla Istanbul Medicine Hospital’e başvuran 23-92 yaşları arasında 688 bireyin serum 25-hidroksi (OH) vitamin D düzeyleri retrospektif olarak incelendi. Bulgular: Olguların %72’sinde vitamin D eksikliği olduğu izlendi (25-OH vitamin D<20 ng/mL). 65 yaş üstü olgularda (n=136) 25-OH Vitamin D düzeyi gençlere göre anlamlı olarak düşük izlendi (n=552) (16,9±12,5 vs. 15,6±13,9 ng/mL, p<0,05). Ayrıca kadın olgularda 25-OH vitamin D düzeyinin erkeklere göre anlamlı olarak düşük olduğu saptandı. (17,2±11,5 vs. 15,9±14,4 ng/mL, p<0,01). Her iki yaş grubu cinsiyetlere göre ayrı ayrı değerlendirildiğinde istatistiksel anlamlılığın devam ettiği görüldü. Sonuç: 65 yaş üstü kadın olgular başta olmak üzere tüm toplumda vitamin D eksikliği taramaları etkin bir şekilde yapılmalıdır.

VITAMIN D LEVELS IN ROUTINE MEDICAL EXAMINATION

DOI: 10.26650/IUITFD.391192Objective: Vitamin D deficiency is a serious public healthcare problem throughout the worldand is related to multiple comorbidities, including osteoporosis, falls, and fractures, particularly in the geriatric population. Materials and Methods: We retrospectively determined the serum 25 hydroxy (OH) vitamin D levels in 688 patients admitted to Istanbul Medicine Hospital for routine medical examination between 2013 and 2016.Results: Serum 25 OH vitamin D levels were <20 ng/mL in 72% of subjects (vitamin D deficiency). The 25 OH vitamin D levels in subjects aged >65 years (n=136) were significantly lower than those in the younger cohort (n=552) (16.9±12.5 vs. 15.6±13.9 ng/mL, p<0.05). Women (n=290) had significantly lower levels than men (n=398) (17.2±11.5 vs. 15.9±14.4 ng/mL, p<0.01). A significant difference was observed between age groups in both genders separately. Conclusion: Vitamin D levels must be monitored widely among the population, especially in elderly women.

___

  • Arıoğlu S. Yaşlıda Malnütrisyon ve Tedavisi. 2013.
  • Pearce SH, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ. 2010;340:b5664.
  • MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536-8.
  • Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988;67(2):373-8.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
  • IOM (Institute of Medicine). 2011. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press. p:345-362.
  • Vieth R. What is the optimal vitamin D status for health? Prog Biophys Mol Biol. 2006;92(1):26-32.
  • Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010;21(7):1151-4.
  • American Geriatrics Society Workgroup on Vitamin DSfOA. Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for Prevention of Falls and Their Consequences. J Am Geriatr Soc. 2014;62(1):147-52.
  • Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S et al. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. 2014; 25(10): 2359–2381.
  • Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011;31(1):48-54.
  • Mansoor S, Habib A, Ghani F, Fatmi Z, Badruddin S, Mansoor S, et al. Prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults. Clin Biochem. 2010;43(18):1431-5.
  • Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-73.
  • Al-Horani H, Abu Dayyih W, Mallah E, Hamad M, Mima M, Awad R, et al. Nationality, Gender, Age, and Body Mass Index Influences on Vitamin D Concentration among Elderly Patients and Young Iraqi and Jordanian in Jordan. Biochem Res Int. 2016;2016:8920503.
  • Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 2009;29(9):3713-20.
  • Jungert A, Neuhauser-Berthold M. Sex-specific determinants of serum 25- hydroxyvitamin D3 concentrations in an elderly German cohort: a cross-sectional study. Nutr Metab (Lond). 2015;12:2.
  • Czernichow S, Fan T, Nocea G, Sen SS. Calcium and vitamin D intake by postmenopausal women with osteoporosis in France. Curr Med Res Opin. 2010;26(7):1667-74.
  • Boucher BJ. The problems of vitamin d insufficiency in older people. Aging Dis. 2012;3(4):313-29.
  • Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr. 2002;75(4):611-5.