Alpay CAKMAK, Ali ATAS, Mustafa SORAN, Dost ZEYREK

Koma Ve Konvülziyon İle Getirilen Akut İzoniazid Zehirlenmesi

Amaç: Konvülziyon ve koma ile gelen akut izoniazid zehirlenmesi olan olguyu sunmak amaçlandı. Olgu: Proflaksi amaçlı başlanan izoniazid tabletlerden 100mg/tb 10 tane alan 8 yaşındaki erkek olgu sunuldu. Beslenme sondası aracılığı ile olguya mide lavajı yapıldı. Mide lavajı sonrasında olguya aktif kömür uygulandı. Acile getirildiği sırada konvülzyonu başlayan olguya diazepam uygulandı ve konvülzyonu 5. dakikada durdu. Antidot olarak Pridoksin 1.5 gr 50 mg/kg/gün intravenöz olarak uygulandı. 8 saatlik takip sonrası hastanın bilinci açıldı. Genel durumu düzeldi. Oral beslenmeye başladı Sonuç: İzoniazid zehirlenmesinde konvülziyonun tedavisinde en iyi yol Pridoksin uygulanmasıdır

Anahtar Kelimeler:

Konvülziyon, İsoniazid, Zehirlenme

Acute Isoniazid Poisoning Presenting With Convulsions And Coma

Purpose: We report a case of acute isoniazid intoxication presented with convulsions, and coma. Case: An 8-year-old boy had taken 10 isoniazid tablets 100mg/tb which had been started as a prophylactic. A nasogastric catheter was administered and gastric lavage was performed followed by the administration of activated charcoal. Immediately after the procedure, sudden convulsions began, which subsided within five minutes of the administration of diazepam infusion. As an antidote, Pyridoxine 1.5 gr 50 mg/kg/day ,was administered intravenously. After 8 hours the patient regained consciousness, his general condition normalized and oral nutrition was started. Conclusions: Pyridoxine administration is the best way of treating convulsions. Parenteral pyridoxine administration is an effective method in isoniazid intoxication

Keywords:

Convulsion, Isoniazid, Intoxication,

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Corresponding Address: Alpay Cakmak, MD Harran University School of Medicine Department of Pediatrics TR-63100, Sanliurfa, TURKEY. Tel: +90 414 3141170 Mobile Phone : +90 5326235956 e-mail: alpaycakmak@gmail.com Fax: +90 414 3151181