Ecmel KAYGUSUZ, Handan ÇETİNER, Meryem EKEN, Cume Yorgancı, Suna CESUR, Hülya YAVUZ, Nermin KOÇ

Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases)

Amaç: Leiomyosarkom uterusun nadir görülen malign bir tümörüdür. Bu retrospektif çalışmada 8 yıllık periotta bölümümüzde değerlendirilmiş leiomyosarkom tanısı almış olgular çalışılmıştır.Materyal-Metod: Ocak 2005 ile Ekim 2013 tarihleri arasında leiomyosarkom tanısı ile opere edilen olguların tüm hastane kayıtları geriye yönelik olarak değerlendirildi. 22 hastaya ait tüm materyeller histolojik olarak değerlendirildi. Bulgular: Yaşları 41 ile 73 arasında değişen (ortalama 54) 22 kadın hasta değerlendirildi. Tümörlerin en geniş çapları 1,5 ile 16 cm arasında değişiyordu (ortalama 8,8). Sonuç: Leiomyosarkom agresif bir neoplazmdır. Leiomyosarkomların tanısı kombine mikroskopik bulgulara dayanmaktadır. Bizim olgularımızın klinikopatolojik verileri literatür verilerine paralellik göstermekteydi.Anahtar Kelimeler: leiomyosarkom, uterus, immunohistokimya, anaplazi, mitotik endeks.AbstractAim: Leiomyosarcoma is a rare malign neoplasm of the uterus. The current retrospective study examined leiomyosarcoma who were evaluated at our institution over a 8 year period.Material-Method: Clinical records of the cases operated with the diagnosis of leiomyosarcoma, between January 2005 and October 2013, reviewed retrospectively. All material belonging to 22 cases were evaluated histologically.Results: There were 22 females, whose age range from 41 to 73 (median 54 years). The neoplasm measured from 1,5 to 16 cm greatest diamater ( median 8,8 cm).Conclusion: In conclusion, leiomyosarcoma is a aggressive neoplasm. The diagnosis of leiomyosarcomas depends on a combination of microscopic features. Our cases clinicopathological correlation values were parallel to the literature.Keywords: Leiomyosarcoma, uterus, immunohistochemistry, anaplasia, mitotic index

Anahtar Kelimeler:

leiomyosarkom, uterus, immunohistokimya, anaplazi, mitotik endeks.

-

Aim: Leiomyosarcoma is a rare malign neoplasm of the uterus. The current retrospective study examined leiomyosarcoma who were evaluated at our institution over a 8 year period.Material-Method: Clinical records of the cases operated with the diagnosis of leiomyosarcoma, between January 2005 and October 2013, reviewed retrospectively. All material belonging to 22 cases were evaluated histologically.Results: There were 22 females, whose age range from 41 to 73 (median 54 years). The neoplasm measured from 1,5 to 16 cm greatest diameter ( median 8,8 cm).Conclusion: In conclusion, leiomyosarcoma is a aggressive neoplasm. The diagnosis of leiomyosarcomas depends on a combination of microscopic features. Our cases clinicopathological correlation values were parallel to the literature.

Keywords:

Leiomyosarcoma, uterus, immunohistochemistry, anaplasia, mitoticindexCiLT: 45 YIL : 2014 SAYI: 2ZEYNEP KAMİL TIP BÜLTENİ 2014;45:65-70KLiNiK ARAŞTIRMA,

PDF

___

Kurman RJ. Blaustein’s Pathology of the Female Genital Tract. In: Zaloudek C, Hendrickson MR (eds). Mesenchymal Tumors of the Uterus. 5th edition. New York: Springer-Verlag; 2002. 561-92.
Tavassolli FA, Devilee P, (eds). World Organization Classification of Tumors Pathology and Genetics, Tumors of the Breast and Female Genital Organs. Lyon: IARC Press, 2003.233-42.
Ryan KJ, Berkowitz RS, Barbieri RL. Kistner’s Gynecology Principles and Practice. In: Muto MG, Friedman AJ (eds). The Uterine Corpus. 6th edition. St. Louis, Missouri: Mosby;1995.159-61.
Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasm. A clinicopathologic study of 213 cases. Am J Surg Pathol.1994;18:535-538.
Van Dinh T, Woodruff JO: Leiomyosarcoma of the uterus. Am J Obstet Gynecol 1982, 144:817-823
Hendrickson MR, Kempson RL: Surgical Pathology of the Uterine Corpus, in Bennington JL(ed): Major problems in Patholgy. Philadelphia, Saunders,1980 Vol12,468-529.
Mayerhofer K, Obermair A, Windbichler G, et al. Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases. Gynecol Oncol. 1999;74:196-201.
Wang WL, Soslow R, Hensley M, Asad H et al. Histopathologic prognostic factors in stage 1 leiomyosarcoma of the uterus: adetailed analysis of 27 cases. Am J Surg Pathol. 2011, 35:522-529
Lusby K, Savannah KB, Demicco EG et al. Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers: A Single Institution’s Experience. Ann Surg Oncol (2013),20:2364-2372
Barter JF, Smith EB, Szpak CA: Leiomyosarcoma of the uterus: a clinicopathologic study of 21 cases. Gynecol Oncol 1985,21:220-227
Schwartz Z, Dgani R, Lancet M,: Uterine sarcoma in Israel: a sudy of 104 cases. Gynecol Oncol 1985, 20:354-363
Evans HL, Chawla Sp, Simpson C: Smooth muscle neoplasm of the uterus other than ordinary leiomyoma: A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988,62:2239-2247.
Bazzocchi F, Brandi G, Pileri S: Clinical and prognostic features of leiomyosarcoma of the uterus. Tumori 1983,69:75-77.
Rauh-Hain JA, Oduyebo T, Diver EJ. Uterine Leiomyosarcoma, an update series. Int J of Gynecol Can. 2013;23:1036-1043.