Koray ASLAN, İbrahim YALÇIN, Hanifi ŞAHİN, Mehmet Mutlu MEYDANLI

LVSI Pozitif ve Grade 1-2 Tümörü Olan Evre IA ve Evre IB Endometrial Kanser Hastalarının Karşılaştırılması: 2016 Yılında ESMO-ESGO ESTRO Tarafından Tanımlanmış Olan Yüksek-Orta Risk Grubunun Analizi

Amaç: Endometrial kanserinde, nüks riski olan hastaları belirlemek ve adjuvan tedavi kullanımına rehberlik etmek amacı ile klinik-patolojik prognostik faktörler kullanılarak risk grupları oluşturulmuştur. Güncel yayınlanan rehberde yeni bir risk grubu tanımlanmış olup evre I endometrioid karsinom, grade 1-2 hastalık ve LVSI pozitif olan olgular myometrial invazyon derinliğinden bağımsız olarak “orta-yüksek” riskli olarak sınıflandırılmıştır. Bu retrospektif çalışmanın amacı evre IA yüksek-orta riskli endometrial kanserli kadınların prognozlarını evre IB Yüksek-orta riskli endometrial kanserli kadınlarla karşılaştırmaktır. Gereçler ve Yöntem: Retrospektif tek merkezli olarak planlanan çalışmada, 2008-2018 tarihleri arasında endometrium kanseri tanısı ile primer tedavi olarak cerrahi ile tedavi edilen tüm hastalar incelendi. Çalışmaya evre I endometroid tip endometrium kanseri olup, LVSI pozitif ve grade 1-2 tümörü olan toplam 46 olgu dahil edildi. Çalışmaya dahil edilen 17 olgu evre IA ve 29 olgu evre IB olmak üzere gruplandırıldı. Olgular için sağ kalım analizleri Kaplan Meier metodu kullanılarak hesaplandı. Bulgular: 5-yıllık DFS oranı evre IA olgular için %94,1 ve evre IB olgular için % 82,3 (p=0.951),5- yıllık OS oranı evre IA olgular için % 94,1 ve evre IB olgular için % 89 (p=0.811) olarak belirlenmiştir. Sonuç: Evre IA, grade 1-2 ve LVSI pozitif endometrial kanserli olgular ve Evre IB, grade 1-2 ve LVSI pozitif endometrial kanserli olguların DFS ve OS oranlarının benzer olduğu görülmüştür

Comparison of Stage IA and Stage IB Endometrial Cancerpatients who were Unequivocally LVSI Positive and Grade 1-2: Analysis of High Intermediate Risk Group which was Currently Defined by ESMO-ESGO-ESTRO Consensus in 2016

Objective: The patients with endometrial cancer have been devised based on clinic-pathological prognostic factors to identify patients at the risk of recurrence and to guide adjuvant therapy use. According to contemporary guidelines, a new risk subgroup has been declared. Regardless of depth of invasion, all patients who were unequivocally LVSI positive and grade 1-2 defined as High-intermediate risk group. The purpose of this retrospective study was to compare the prognoses of women with stage IA high-intermediate endometrial cancer to those women of stage IB High-intermediate endometrial cancer. Material and Methods: A single center, retrospective department database review was performed to identify patients with endometrial Cancer. A total of 46 women with Stage I endometrial cancer who were unequivocally LVSI positive and grade 1-2 between 2008 and 2018 were included in this retrospective study. Seventeen (37%) were classified as Stage IA and 29 (63%) as Stage IB. Kaplan-Meier method was used to generate survival data. Results: The 5-year disease-free survival (DFS) rate was 94.1% versus 82.3%(p=0.95) and 5-year overall survival (OS) was94.1% versus 89% (p=0.81) for stage IA and stage IB, respectively. Conclusion: DFS and OS rates of patients with Stage IA, grade 1-2 and LVSI positive endometrial cancer and Stage IB, grade 1-2 and LVSI positive endometrial cancer seem to be similar

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