KTB Uterin Karsinosarkomlarda İmmunohistokimyasal Olarak C-KIT Ekspresyonunun Değerlendirilmesi

Amaç: Karsinosarkom oldukça agresif bir neop- lazmdır. KIT-pozitif neoplazmlarda tirozin kinaz in- hibitörleri tedavide başarılı sonuçlar vermektedir. Bu nedenle, bu tümörlerde c-kit ekspresyonu klinik açıdan önemli olabilir. Bu çalışmanın amacı, kar- sinosarkomun karsinomatöz ve sarkomatöz kompo- nenetlerinde c-kit ekspresyonunu incelemek ve bu neoplazmlarda KIT’in terapötik bir hedef olarak kullanılabilirliğini saptamaktır.

C-KIT Ekspresyonunun Değerlendirilmesi Immunohistochemical Evaluation of C-KIT Expression in Uterine Carcinosarcomas

Objective: Carcinosarcoma is a very aggressive neoplasm. The use of tyrosine kinase inhibitors has resulted in successful treatment of KIT-positi- ve neoplasms. Consequently, c-kit expression may have significant clinical implications for this tumor. The purpose of the present study was to assess c-kit expression in the carcinomatous and sarcomatous component of carcinosarcoma and to identify if KIT represents a therapeutic target for treatment of this neoplasm.

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