Rabia Gönül SEZER, İlke İPEK ÖZAHİ, Abdülkadir BOZAYKUT, Lale Pulat SEREN, CEM PAKETÇI, İLHAN ASYA TANJU

Kistik fibroziste atipik kolonizasyon

Giriş: Kronik bakteriyeî havayolu kolonizasyonları kistik fibrozis hastalarındaki mortalite ve morbiditenin ana sebeplerindendir. Olgu Sunumu: Kistik fibrosis tanısı konulan 4 aylık erkek hastanın birer hafta ara ile alınan derin trakeal aspirasyon kültürlerinde Enterobacteria, Metisilline hassas Staphylococcus aerius ve 2 kez E.coli üremesi saptandı. Hastaya sırasıyla gentamisin, sefuroksim aksetti ve sefoperazon tedavileri verildi. Hastadaki bu üremeler atipik kolonizasyon olarak değerlendirildi. Sonuç: Enfeksiyon tedavisi gereken kistik fibrozis hastalarına antibiyotik tedavisi planlanırken yeni bildirilen kolonizasyonlar da göz önünde bulundurulmalıdır.

Anahtar Kelimeler:

-

Atypical colonization in cystic fibrosis

Objective: Chronic bacterial colonization is the leading cause of morbidity and mortality in patients with cystic fibrosis. Case Report: Deep tracheal aspiration cultures of a-4-months old boy with cystic fibrosis revealed Enterobacteria, Metisillin Sensitive Staphylococcus aerius and E.coli with 1 week intervals. He was treated with gentamicin, sefuroxime axetil, cefoperazone respectively. All these results were taken as atypical colonizations in our patient. Conclusion: Antibiotic treatment targetting these new colonizations, in addition to the primary colonizing pathogens, may improve the management of infective exacerbations of cystic fibrosis.

Keywords:

-,

PDF

___

1- Çetin İ. Kistik fibroziste solunum sistemi belirtileri. Katkı Pediatri Dergisi 2002;23(2):150-6
2- Field TR, Sibley CD, Parkins MD, Rabin HR, Surette MG. The genus Prevotella in cystic fibrosis airways. Anaerobe 2010; 20. [Epub ahead of print] 3- George AM, Jones PM, Middleton PG. Cystic fibrosis infections: treatment strategies and prospects. FEMS Microbiol Lett 2009;300(2):153-64
4- Hill RL, Kearns AM, Nash J et al.Linezolid-resistant ST36 methicillin-resistant Staphylococcus. aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients. J Antimicrob Chemother 2010;65(3):442-5
5- Tunney MM, Field TR, Moriarty TF et al. Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am J Respir Crit Care Med 2008;177(9):995-1001
6- Chotirmall SH, O'Donoghue E, Bennett K, Gunaratnam C, O'Neill S J, McElvaney NG. Sputum Candida Albicans presages FEV1 decline and hospitalized exacerbations in cystic fibrosis. Chest 2010. [Epub ahead of print] 7- Giraud S, Pihet M, Razafimandimby B et al. Geosmithia argillacea : an emerging pathogen in cystic fibrosis patients ? J Clin Microbiol 2010. [Epub ahead of print] 8-Hatziagorou E, Walsh TJ, Tsanakas JN, Roilides E. Aspergillus and the paediatric lung. Paediatr Respir Rev 2009;10(4):178-85
9-Griffard E A, Guajardo JR, Cooperstock MS, Scoville CL. Isolation of Exophiala dermatitidis from pigmented sputum in a cystic fibrosis patient. Pediatr Pulmonol 2010;45(5):508-10
10-Bittar F, Stremler N, Audie JP et al. Nocardia farcinica lung infection in a patient with cystic fibrosis: a case report. J Med Case Reports 2010;8(4):84
11-Beucher J, Belleguic C, Brinchault G, Deneuville E, Donnio PY, Roussey M. Nocardia farcinica infection in a patient with cystic fibrosis. Rev Mai Respir 2010;27(l):76-9
12-SmithJJ, Travis SM, GreenbergEP, Welsh MJ. Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid. Cell 1996;85(2):229-36