Masum KAYAPINAR, Gökalp ŞENOL, Gökhan ÜNVER, Zafer BÜTÜN, Kamuran SUMAN

The value of measurement of vaginal fluid creatinine and beta-human chorionic gonadotropin in the diagnosis of premature rupture of membranes

Objective: The purpose of the present study is to evaluate β-human chorionic gonadotropin (β-hCG) and creatinine levels in the vaginal fluid regarding to diagnosis of premature rupture of membranes (PROM). Material and Methods: This study was conducted on 150 pregnant women in the third trimester (28–40 weeks). The patients were grouped as: (1) PPROM group (75 cases) and (2) intact membranes as control group (75 cases). Three milliliters of sterile normal saline were inserted into the posterior fornix of the vagina and then vaginal fluid was aspirated. Creatinine and β-hCG levels in the vaginal fluid were measured β-hCG and creatinine levels were compared between the two groups. Results: The mean vaginal fluid level in Groups 1 and 2 was 0.60±0.72 (0.37) and 0.22±0.11 (0.2) for creatinine and β-hCG which was positive in 411.69±605.65 (146) and 12.71±24.63 (3.9), respectively. There was a statistically significant difference regarding to mean creatinine and β-hCG levels between two groups (p

PDF

___

1. Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol 2003;101(1):178–93.
2. Aagaard-Tillery KM, Nuthalapaty FS, Ramsey PS, Ramin KD. Preterm premature rupture of membranes: Perspectives surrounding controversies in management. Am J Perinatol 2005;22(6):287–97.
3. Garite TJ. Management of premature rupture of membranes. Clin Perinatol 2001;28(4):837–47.
4. Meis PJ, Goldenberg RL, Mercer BM, Iams JD, Moawad AH, Miodovnik M, et al. The preterm prediction study: Risk factors for indicated preterm births. Maternal-fetal medicine units network of the national ınstitute of child health and human development. Am J Obstet Gynecol 1998;178(3):562-7.
5. Gibbs RS, Karlan BY, Haney AF, Nygaard I. Erken membran rüptürü. In: Danforth’s Obstetrik ve Jinekoloji. 10th ed. Baskı. Ankara: Güneş Tıp Kitabevleri; 2010. p. 186–976.
6. Davidson KM. Detection of premature rupture of the membranes. Clin Obstet Gynecol 1991;34(4):715–22.
7. Abbott DS, Radford SK, Seed PT, Tribe RM, Shennan AH. Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women. Am J Obstet Gynecol 2013;208(2):122.e1–6.
8. Akercan F, Cirpan T, Kazandi M, Terek MC, Mgoyi L, Ozkinay E. The value of the insulin-like growth factor binding protein-1 in the cervical-vaginal secretion detected by immunochromatographic dipstick test in the prediction of delivery in women with clinically unconfirmed preterm premature rupture of membranes. Eur J Obstet Gynecol Reprod Biol 2005;121(2):159–63.
9. Lee SE, Park JS, Norwitz ER, Kim KW, Park HS, Jun JK. Measurement of placental alpha-microglobulin-1 in cervicovaginal discharge to diag-nose rupture of membranes. Obstet Gynecol 2007;109(3):634–40.
10. Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A. The value of urea, creatinine, prolactin, and beta sub-unit of human chorionic gonadotropin of vaginal fluid in the diagnosis of premature preterm rupture of membranes in pregnancy. Turk J Obstet Gynecol 2016;13(2):62–6.
11. Anai T, Tanaka Y, Hirota Y, Miyakawa I. Vaginal fluid hCG levels for detecting premature rupture of membranes. Obstet Gynecol 1997;89(2):261–4.
12. Kafali H, Oksüzler C. Vaginal fluid urea and creatinine in diagnosis of premature rupture of membranes. Arch Gynecol Obstet 2007;275(3):157–60.
13. Zanjani MS, Haghighi L. Vaginal fluid creatinine for the detection of premature rupture of membranes. J Obestet Gynaecol Res 2011;38(3):505–8.
14. Cooper AL, Vermillion ST, Soper DE. Qualitative human chorionicgonadotropin testing of cervicovaginal washings for the detection of preterm premature rupture of membranes. Am J Obstet Gynecol 2004;191(2):593–7.
15. Mohamed AM, Mostafa WA. The value of measurement of vaginal fluid urea, creatinine and beta HCG in the diagnosis of premature rupture of membranes. Kasr Al‐Aini J Obstet Gynecol 2011;2(2):41–7.
16. Tığlı A, Kurt S, Kopuz A. Erken membran rüptürü tanısında vajinal yıkama sıvısında beta-insan koryonik gonadotropin, kreatinin ve ürenin yeri. Perinatol Derg 2014;22(4):133–7.
17. Kuruoğlu YS, Bıldırcın FD, Karlı P, Özdemir AZ. Use of vaginal creatinine levels in detecting premature rupture of membranes Erken memran rüptürü tespitinde vajinal kreatinin seviyelerinin kullanılması. J Surg Med 2019;3(6):421–7.
18. Abdelazim IA, Makhlouf HH. Placental alpha microglobulin-1 (AmniSure® test) for detection of premature rupture of fetal membranes. Arch Gynecol Obstet 2012;285(4):985–9.
19. Kariman N, Hedayati M, Majd SA. The diagnostic power of cervico-vaginal fluid prolactin in the diagnosis of premature rupture of membranes. Iran Red Crescent Med J 2012;14(9):541–8.