BURHANETTİN BAYDAŞ, Fahri BAYIROĞLU, İsmail MERAL, Ramzan ŞEKEROĞLU, Ramzan ÜSTÜN

Digoksin ile tiroid hormonları arasındaki ilişkinin araştırılması

Bu çalışma, kalp glıkozıdlerınden digoksının tiroid hormonları seviyesi üzerine olan etkisinin araştırılması amacıyla yapıldı. Çalışmada canlı ağırlık ortalamaları 1400-1600 gr arasında değişen 16 adet Yem Zelanda ırkı tavşan kullanıldı Digoksin grubuna 1 mg/kg dozunda digoksin kas içi (i.m.) enjekte edildi. Kontrol grubuna ise uygulanan digoksinin mililitresi kadar serum fizyolojik enjekte edildi. Deney süresinin bitiminde tavşanlardan kan alınarak parametrelere bakıldı. Digoksin uygulanan grupta, serum tiroksin (T4) seviyelerinde belirgin bir azalma görüldü ve bu azalmanın istatistiksel anlamda önemli olduğu saptandı (P

Anahtar Kelimeler:

kardiak glikozidler, tiroit bezi, digoksin, tavşan

Investigation of relationeship between digoxin and thyroid hormones

This study was planned to investigate the possible effect of Digoxin, a cardiac glicoside, on the thyroid hormone levels Sixteen rabbits (New Zealand), weighting about 1400-1600 gr, were used. Digoxin was injected to the digoxin-treated group 1 mg/kg intramusculary (i.m) and serum physiologic (%0.85) was injected to control group i.m. at the same dose. Blood was taken from rabbits eight hours later, and parameters were measured. Serum thyroxme (T4) and tniodothyronme levels of the digoxin-treated group were significantly lower (P<0.05).than these of control group. On the other hand, glucose level of the digoxin-treated group which is closely related to thyroid hormones increased statistically (P<0.05). Althoug no change was observed in the protein level., a statistically significant increase (P<0.05) was found in the lactic dehidrogenase (LDH) and serum glutamic pruvice transaminase (SGPT) levels of the digoxin-treated group.

Keywords:

cardiac glycosides, thyroid gland, digoxin, rabbits,

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