Histological evaluation of implantation deficit in experimentally induced e ndometriosis model of rats

Deneysel olarak indüklenmiş sıçan endometriyozis modelinde implantasyon kusurunun histolojik değerlendirilmesi

Background: Experimental animal models are impor- tant in understanding human endometriotic disease. Aims: This study aims to describe factors influencing the implantation deficit in experimental endometriosis. Material and Method: Decidua reaction were detected in surgical endometriosis induction group (n=20), sham operated (n=10) and non-operated control (n=10) groups and studied with routine light microscopic, electron microscopic and immunohistochemical techniques as well as histologic, morphometric and biochemical analysis. Results: Decidualisation and pinopode expression of eutopic endometrium in surgically induced endometriosis relatively decreased and adequate endometrial morpho- logy may not always display normal endometrial receptivity. Although mitotic figures were described, study groups revealed statistically significant thickness differences in morphometry. Conclusions: Uterine receptivity defects are regulated differently while other alternative mechanisms effecting endometrial receptivity sustained. In addition, unsignifi- cant differences of immunohistochemical expressions are non-descriptive due to the antibodies used for uterine receptivity in experimental endometriosis. Yet, morpho- metry may pioneer novel ultrasonographic modules in future.

Kaynakça

1. Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis European Journal of Obstetrics, Gynecology, and Reproductive Biology 2001;96(1):21-34.

2. DeCherney AH, Lauren, N. Endometriosis. in DeCherney AH, editors. 10 th ed. Current Obstetric & Gynecologic Diagnosis & Treatment. Ohio, McGraw-Hill Companies; 2003.p.801-7.

3. Yao Z, Shen X, Capodanno I, Donnelly M, Fenyk-Melody J, Hausamann J, et al. Validation of rat endometriosis model by using raloxifene as a positive control for the evaluation of novel SERM compounds J Invest Surg 2005;18(4):177-83.

4. Xue Q, Lin Z, Yin P, Milad MP, Cheng YH, Confino E, et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis. J Clin Endocrinol Metab 2007;92:3261- 7.

5. Maruyama T, Yoshimura Y. Molecular and cellular mechanisms for differentiation and regeneration of the uterine endometrium. Endocrine Journal 2008,55(5):795-810.

6. Nezhat F, Datta MS, Hanson V, Pejovic T, Nezhat C. The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril 2008;90(5):1559-70.

7. Ohlsson Teague EMC, Van der Hoek KH, Van der Hoek MB, Perry N, Wagaarachchi P, Robertson SA, et al. MicroRNA-regulated pathways associated with endometriosis. Mol Endocrinol 23(2):265-75.

8. Zhou HE, Nothnick WB. The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis. Front Biosci 2005;10:569-75.

9. Braundmeier AG, Fazleabas AT.The Non-Human Primate Model of Endometriosis: Research and Implications for Fecundity. Mol Hum Reprod 2009;15(10):577–86.

10. Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil Steril 2010; 93(8):2519-24.

11. Rosa-e-Silva JC, Garcia SB, de Sá Rosa-e-Silva AC, Candido-dos- Reis FJ, Poli-Neto OB, Ferriani RA, et al. Increased cell proliferation in experimentally induced endometriosis in rabbits. Fertil Steril 2010;93(5):1637-42.

12. Chrobak A, Sieradzka U, Sozanski R, Chelmonska-Soyla A, Gabrys M, Jerzak M. Ectopic and eutopic stromal endometriotic cells have a damaged ceramide signaling pathway to apoptosis. Fertil Steril 2009; 92(6):1834-1843.

13. Bruner-Tran KL, Eisenberg E, Yeaman GR, Anderson TA, McBean J, Osteen KG. Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J Clin Endocrinol Metab 2002;87(10): 4782.

14. Ulukus M, Cakmak H, Arici A. The role of endometrium in endometriosis. J Soc Gynecol Investig 2006;13(7):467-476.

15. Hansen PJ. Regulation of immune cells in the uterus during pregnancy in ruminants. J Anim Sci 2007;85(13 suppl):E30-1.

16.Serle E, Aplin JD, Li TC, Warren MA, Graham RA, Seif MW, et al.Endometrial differentiation in the peri-implantation phase of women with recurrent miscarriage: a morphological and immunohisto- chemical study. Fertil Steril 1994; 62(5):989-96.

17.Senturk LM, Arici A. Immunology of endometriosis. J Reprod Immunol 1999;43(1):67-83.

18. Selam B, Arici A. Implantation defect in Endometriosis: endometrium or peritoneal fluid. J Reprod Fertil Suppl 2000;55:121-8.

19.Vercammen EE, D'Hooghe TM. Endometriosis and recurrent pregnancy loss. Seminars in Reproductive Medicine 2000;18(4):363-8.

20. Sidell N, Han SW, Parthasarathy S. Regulation and modulation of abnormal immune responses in endometriosis. Annals of the New York Academy of Sciences 2002;955:159–73.

21.Vinatier D, Dufour P, Oosterlynck D. Immunological aspects of endometriosis. Hum Reprod Update 1996;2(5):371-84.

22.Vernon MW, Wilson EA. Studies on the surgical induction of endometriosis in the rat. Fertil Steril 1985;44(5):684-94.

23. Rajkumar K, Schott PW, Simpson CW. The rat as an animal model for endometriosis to examine recurrence of ectopic endometrial tissue after regression. Fertil Steril 1990;53(5):921-5.

24. Yang JZ, Foster WG. Continuous exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin inhibits the growth of surgically-induced endometriosis in the ovariectomized mouse treated with high dose estradiol. Toxicol Ind Health 1997;13(1):15-25.

25.Marcondes FK, Bianchi FJ, Tanno AP. Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol 2002;62(4A):609-14.

26. Dursun A, Sendag F, Terek MC, Yilmaz H, Oztekin K, Baka M, et al. Morphometric changes in the endometrium and serum leptin levels during the implantation period of the embryo in the rat in response to exogenous ovarian stimulation. Fertil Steril. 2004 Oct;82 Suppl 3:1121-6.

27. Sheehan DC, Hrapchak BB. Theory and Practice of Histotechnology. Ohio, Battelle Memorial Institute;1987.

28. Sözmen EY, Tanyalçin T, Onat T, Kutay F, Erlaçin S. Ethanol induced oxidative stress and membrane injury in rats. Eur J Clin Chem Clin Biochem 1994;32(10):741-4.

29. Sampson JA.Perforating hemorrhagic (chocolate) cysts of the ovary. Their importance and especially their relation to pelvic adenomas of the endometrial type ("adenomyoma" of the uterus, rectovaginal septum, sigmoid, etc.). Arch Surg 1921;3: 245-323.

30. Ulukus M, Ulukus EC, Tavmergen Goker EN, Tavmergen E, Zheng W, Arici A, et al. Expression of interleukin-8 and monocyte chemotactic protein 1 in women with endometriosis. Fertil Steril 2009;91(3):687-93.

31. Story L, Kennedy S. Animal studies in endometriosis: a review. ILAR J 2004;45:132-8.

32. Grümmer R. Animal models in endometriosis research. Hum Reprod Update 2006;12(5):641-9.

33. O'Shea JD, Kleinfeld RG, Morrow HA. Ultrastructure of decidualization in the pseudopregnant rat. Am J Anat 1983 ;166(3):271-98.

34.Usadi RS, Murray MJ, Bagnell RC, Fritz MA, Kowalik AI, Meyer WR, et al. Temporal and morphologic characteristics of pinopod expression across the secretary phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril 2003;79(4):970-4.

35. Psychoyos A. Hormonal control of uterine receptivity for nidation. J Reprod Fertil-Suppl 1976;25:17-28.

36.Psychoyos A. Uterine receptivity for nidation. Ann NY Acad Sci 1986;476:36-42.

37. Psychoyos A, Nikas G. Uterine pinopodes in peri-implantation human endometrium. Clinical relevance. Ann N Y Acad Sci 1997;816:129-42.

38. Murphy CR. Understanding the apical surface markers of uterine receptivity: pinopods-or uterodomes? Hum Reprod 2000;15 (12):2451-4.

39. Murphy R. Junctional barrier complexes undergo major alterations during the plasma membrane transformation of uterine epithelial cells. Hum Reprod 2000;15(Suppl 3):182-8.

40. Martel D, Monier MN, Roche D,Psychoyos A. Hormonal dependence of pinopode formation at the uterine luminal surface. Human Reprod 1991;6(4):597-603.

41. Warren RH, Enders AC. An Electron Microscope Study Of The Rat Endometrium During Delayed Implantation Anat Rec 1964;148: 177-95.

42. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update 2006;12(6):731- 46.

43. Horcajadas JA, Riesewijk A, Domínguez F, Cervero A, Pellicer A, Simón C. Determinants of endometrial receptivity. Ann NY Acad Sci 2004; 1034:166-75.

44. Zorn TM, Bevilacqua EM, Abrahamsohn PA. Collagen remodeling during decidualization in the mouse. Cell Tissue Res 1986;244(2):443-8.

45. Ordi J, Creus M, Casamitjana R, Cardesa A, Vanrell JA, Balasch J. Endometrial pinopode and alphavbeta3 integrin expression is not impaired in infertile patients with endometriosis. J Assist Reprod Genet 2003;20(11): 465-73.

46. Garcia-Velasco JA, Nikas G, Remohí J, Pellicer A, Simón C. Endometrial receptivity in terms of pinopode expression is not impaired in women with endometriosis in artificially prepared cycles. Fertil Steril 2001;75(6):1231-3.

47.Tuckerman E, Laird SM, Stewart R, Wells M, Li TC. Markers of endometrial function in women with unexplained recurrent pregnancy loss: a comparison between morphologically normal and retarded endometrium. Hum Reprod 2004;19(1):196-205.

48. Welsh AO, Enders AC. Occlusion and reformation of the rat uterine lumen during pregnancy. Am J Anat 1983;167(4):463-77.

49. Welsh AO, Enders AC. Light and electron microscopic examination of the mature decidua cells of the rat with emphasis on the antimesometrial decidual and its degeneration. Am J Anat 1985; 172:1-29.

50. Welsh AO, Enders AC. Chorioallontoic placenta formation in the rat: I. Luminal epithelial cell death and extracellular modification in the mesometrial region of implantation chambers. Am J Anat 1991;192:215-33.

Kaynak Göster

Yeni Tıp Dergisi
  • ISSN: 1300-2317
  • Yayın Aralığı: Yılda 0 Sayı
  • Başlangıç: 2018

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