Ratlarda parasetamol ile indüklenen nefrotoksisite modelinde eser elementler ve antioksidan kapasite üzerine borun etkisinin araştırılması

Bu çalışmada, parasetamol ile indüklenen nefrotoksisite modelinde borun eser element ve antioksidan kapasiteye etkisi araştırıldı. Çalışmanın amacı, borun antioksidan aktivitesinin, eser elementler ve vücudumuzdaki antioksidan kapasiteye etkisi olup olmadığını gösterme açısından benzersiz bir değere sahiptir. Çalışmada 56 albino Wistar rat 7 gruba ayrıldı: Grup 1 (Kontrol); Grup 2 (Parasetamol); Grup 3 (Parasetamol + 50 mg / kg bor); Grup 4 (Parasetamol + 100 mg / kg bor); Grup 5 (Parasetamol + 200 mg / kg bor); Grup 6 (Parasetamol + 140 mg / kg N-Asetilsistein (NAC)); Grup 7 (200 mg / kg bor). Araştırma sonunda, sıçanlardan alınan doku örnekleri iz element analizi için kullanılmıştır (Magnezyum (Mg), Manganez (Mn), Kobalt (Co), Bakır (Cu), Çinko (Zn), Selenyum (Se)), Malondialdehit (MDA), toplam antioksidan durumu (TAS), toplam oksidan durumu (TOS), süperoksit dismutaz aktivitesi (SOD), katalaz aktivitesi (CAT) ve glutatyon peroksidaz (GPx) analizleri. Aynı şekilde, sıçanların kalbinden alınan kan örnekleri de kreatinin kan üre azotu (BUN) analizleri için incelendi. Bulgular sonucunda bu çalışma, borun antioksidan özelliklere sahip olabileceğini ve parasetamol ile indüklenen nefrotoksisitede iz elementler ve antioksidan kapasite üzerinde koruyucu bir etkisi olabileceğini göstermektedir.

Investigation of boron effect on trace elements and antioxidant capacity in paracetamol-induced nephrotoxicity model

In this study, the effect of boron on the trace element and antioxidant capacity in paracetamol induced nephrotoxicitymodel was investigated. The main hypothesis on which the study is based has a unique value in terms of showing whetherthe antioxidant activity of boron has an effect on the trace elements and antioxidant capacity in our body. In the study, 56albino Wistar rats were divided into 7 groups: Group 1 (Control); Group 2 (Paracetamol); Group 3 (Paracetamol + 50mg/kg boron); Group 4 (Paracetamol + 100 mg/kg boron); Group 5 (Paracetamol + 200 mg/kg boron); Group 6(Paracetamol + 140 mg/kg NAC); Group 7 (200 mg/kg boron). At the end of the research, tissue samples taken from ratswere used for trace element analysis (Magnesium (Mg), Manganese (Mn), Cobalt (Co), Copper (Cu), Zinc (Zn), Selenium(Se), Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase activity(SOD), catalase activity (CAT) and glutathione peroxidase (GPx) analyses. Likewise, blood samples taken from the heartsof rats were examined for creatinine blood urea nitrogen (BUN) analyses. As a result of the findings, this study suggeststhat the boron may have antioxidant properties and may have a protective effect on trace elements and antioxidant capacityin paracetamol-induced nephrotoxicity.

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