Koyunlara Damar İçi ve Kas İçi Tek Doz Uygulanan Uzun Etkili Oksitetrasiklinin Biyoyararlanımı ve Farmakokinetiği Üzerine Prednizolonun Etkisi

Bu çalışmada, koyunlara tek doz (20 mg/kg, canlı ağırlık) kas içi ve damar içi uygulandıktan sonra uzun etkili oksitetrasiklinin farmakokinetiği ve prednizolon ile eş-zamanlı kas içi uygulamayı takiben de muhtemel farmakokinetik etkileşimin belirlenmesi amaçlandı. İlacın plazma yoğunluğu ELISA prosedürü ile ölçüldü. Kas içi ve damar içi uygulamadan sonra oksitetrasiklinin plazma yoğunluğu-zaman eğrisinin iki bölmeli açık modele uygunluğu tüm kinetik hesaplamalarda dikkate alındı. Oksitetrasiklin ve prednizolonun kas içi yolla kombine tarzda eş-zamanlı olarak uygulanması sonrası elde edilen farmakokinetik parametreler, tek başına uygulanan ilaç parametreleri ile benzerlik gösterdi (p > 0.05). Dolayısıyla, sonuç olarak, uzun etkili oksitetrasiklinin tek başına veya prednizolon ile birlikte uygulandığında plazmada 48 saat boyunca ortalama terapötik düzeyi sağladığı ve prednizolonla birlikte uygulama durumunda ise olumlu veya olumsuz herhangi bir etkileşimin olmadığı kanısına varıldı.

Anahtar Kelimeler:

Farmakokinetik, Koyun, Oksitetrasiklin, Prednizolon

PDF

___

Adawa DA., Hassan AZ., Abdullah SU., Ogunkoya AB., Adeyanju JB., Okoro JE. 1992. Clinical trial of long-acting oxytetracycline and piroxicam in the treatment of canine ehrlichiosis. Vet. Q., 14, 118-120.
Banting AL., Baggot JD. 1996. Comparison of the pharmacokinetics and local tolerance of three injectable oxytetracycline formulations in pigs. J. Vet. Pharmacol. Ther., 19, 329.
Cornwell RL. 1980. Evaluation of a long-acting injectable oxytetracycline. Mod. Vet. Pract., 61, 954-957.
Craigmill AL., Holland RE., Robinson D., Wetzlich S., Arndt T. 2000. Serum pharmacokinetics of oxytetracycline in sheep and calves and tissue residues in sheep following a single intramuscular injection of a long-acting preparation. J. Vet. Pharmacol. Ther., 23, 345-352.
El Korchi G., Prats C., Arboix M., Perez B. 2001. Disposition of oxytetracycline in pigs after i.m. administration of two longacting formulations. J. Vet. Pharmacol. Ther., 24, 247-250.
Elsheikh HA., Osman IA., Ali BH. 1997. Comparative pharmacokinetics of ampicillin trihydrate, gentamicin sulphate and oxytetracycline hydrochloride in Nubian goats and desert sheep. J. Vet. Pharmacol. Ther., 20, 262-266.
Escudero E., Carceles CM., Ponferrada C., Baggot JD. 1996. Pharmacokinetics of a long-acting formulation of oxytetracycline in sheep and goats. J. Vet. Pharmacol. Ther., 19, 75–77.
Escudero E., Carceles CM., Serrano JM. 1994. Pharmacokinetics of oxytetracycline in goats: modifications induced by a longacting formulation. Vet. Rec., 135, 548- 552.
Ferguson DC., Hoeing M. 2001. Glucocordicoids, Mineralocordicoids, and Steroid Synthesis Inhibitors. In: Veterinary Pharmacology and Therapeutics. Adams, HR., (Ed)., 8th Edit., Chapter 33. Iowa State University Press, Ames, IA., pp. 649-671.
Gardner IA., Hird DW., Franti CE., Glenn JS. 1989. Randomized efficacy trials of longacting oxytetracycline in neonatal pigs. J. Am. Vet. Med. Assoc., 194, 659-663.
George LW., Smith JA. 1985. Treatment of Moraxella bovis infections in calves using a long-acting oxytetracycline formulation. J. Vet. Pharmacol. Ther., 8(1), 55-61.
Immelman A., Van Rensburg JJ. 1983. Oxytetracycline plasma concentrations in sheep after the administration of a polyvinylpyrrolidone formulation. J. S. Afr. Vet. Assoc. 54, 241-242.
Kaya S. 2002. Kemoterapötikler (AntibiotiklerTetrasiklinler) İçinde: Veteriner Hekimliğinde Farmakoloji. Editörler, Kaya S., Pirinçci İ., Bilgili A. 13. Bölüm., Cilt 2., Baskı 3., Medisan yayınları, Ankara, s. 265-350.
Kaya S., Yarsan E., Baydan E., Akkaya R., Aksoy A. 2001. Comparison of the pharmacokinetics of conventional and long-acting formulations of oxytetracycline in sheep. Turk. J. Vet. Anim. Sci., 25, 173-177.
Kikuvi GM., Mitema ES., Buoro IB. 2001. The pharmacokinetics of a long-acting oxytetracycline formulation in healthy dogs and in dogs infected with Ehrlichia canis. Vet. Res. Commun., 25, 391-400.
Kumar R., Malik JK. 1998. Some pharmacokinetic parameters and dosage regimens for a long-acting formulation of oxytetracycline in 6- to 8-month-old male calves. Vet, Res. Commun., 22, 533-544.
Moreno L., Serrano JM., Guimera ME., Carceles CM. 1998. Pharmacokinetics of oxytetracycline after intramuscular administration with lidocaine in sheep, comparison with a conventional formulation. Res. Vet. Sci., 65, 209-213.
Oukessou M., Uccelli-Thomas V., Toutain PL. 1992. Pharmacokinetics and local tolerance of a long-acting oxytetracycline formulation in camels. Am. J. Vet. Res., 53, 1658-1662.
Palmer JE., Benson CE., Whitlock RH. 1992. Effect of treatment with oxytetracycline during the acute stages of experimentally induced equine ehrlichial colitis in ponies. Riviere JE., Spoo JW. 2001. Tetracycline Antibiotics. In: Veterinary Pharmacology and Therapeutics. Adams, HR., (Ed)., 8th Edit., Chapter 42. Iowa State University Press, Ames, IA., pp. 828-840. H Am. J. Vet. Res., 53, 2300-2304. Rowland M., Tozer TN. 1989. Clinical Pharmacokinetics, Concepts and Applications. Chapter 11-12. 2 th Edit., Lea and Febiger Ltd., Pennsylvania, USA, pp.151-178.
Payne MA., Babish JG., Bulgin M., Lane M., Wetzlich S., Craigmill AL. 2002. Serum pharmacokinetics and tissue and milk residues of oxytetracycline in goats following a single intramuscular injection of a long-acting preparation and milk residues following a single subcutaneous injection. J. Vet. Pharmacol. Ther., 25, 25- 32.
Smith JA., George LW. 1985. Treatment of acute ocular Moraxella bovis infections in calves with a parenterally administered long-acting oxytetracycline formulation. Piekoszewski W., Chow FS., Jusko WJ. 1994. Am. J. Vet. Res., 46(4), 804-807.
Pharmacokinetic and pharmacodynamic effects of coadministration of methylprednisolone and tacrolimus in rabbits. J. Pharmacol. Exp. Ther., 269, 103-109.
TerHune TN., Upson DW. 1989. Oxytetracycline pharmacokinetics, tissue depletion, and toxicity after administration of a long-acting preparation at double the label dosage. J. Am. Vet. Med. Assoc.,
Post LO., Cope CV., Farrell DE., Baker JD., 194, 911-917. Myers MJ. 2001. Influence of porcine actinobacillus pleuropneumoniae ınfection and dexamethasone on the pharmacokinetic parameters of enrofloxacin J. Pharmacol. Exp. Ther. 301, 217-227.
Toutain PL., Bousquet-Melou A. 2004. Plasma clearance. J. Vet. Pharmacol. Ther., 27, 415-425.
Traş B., Elmas M. 2005. Klinik Farmakokinetik. Konya, Selçuk Üniversitesi Yayınları. s. 10-11. Riviere J. 1999. Comparative Pharmacokinetics, Principles, Techniques, and Applications. Iowa State University Press, Ames, IA.
Traş B., Yazar E., Elmas M. 2007. Veteriner Hekimliğinde İlaç Kullanımına Pratik ve Akılcı Yaklaşım. 2.Baskı. Konya, s. 213- 224. Riviere JE., Spoo JW. 1995. Tetracycline antibiotics. In: Veterinary Pharmacology and Therapeutic. Adams, RH. (Ed.), 7 th Edit., Iowa State University Press, Ames, Iowa, pp. 785-796.
Yamaoka K., Nakagawa T., Uno T. 1978. Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm., 6, 547-558.