Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats
Calcium ions are very important for many sperm
functions involving sperm motility, reaction, and hyperactivation. The purpose
of this study was to examine the effect of calcium channel blocker (CCB),
Amlodipine (AML), on spermatological features, genital tract weight and
spermatogenic cell density in adult male Wistar rats. Twelve rats (age, 12
weeks; weight, 290-350 g) were divided into two groups, six rats per each.
Group I rats were fed normal diet without AML served as the control, Group II
received 0.04 mg/daily AML for 30 days by oral gavage. Motility, left testis,
right epididymis, prostate weight were decreased, and abnormal sperm rate was significantly
(P<0.05) increased in AML groups compared with control group. The
seminiferous tubular diameter and germinal cell layer thickness were not
affected compared with control group. In conclusion, subacute administration of
AML to male rats have detrimental effects on the spermatological parameters and
genital tract weights, but not affect spermatogenic cell density of male rats.
Anahtar Kelimeler:
Amlodipine, Rat, Spermatologic parametres
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- Başlangıç: 2022
- Yayıncı: Atatürk Üniversitesi