Emine KAYGILI, Ömer Faruk TURAN, Ozlem TASKAPİLİOGLU, Bahattin HAKYEMEZ, Aylin BİCAN DEMİR

Relapsing Remitting Multipl Skleroz Hastalarında Ekstrakraniyal ve İntrakraniyal Venöz Yapıların Doopler Sonografi, Kraniyal MR Venografi ve Selektif Venografi ile Değerlendirilmesi ve Sağlıklı Kontroller ile Karşılaştırılması

Son yıllarda Multipl skleroz (MS) etyolojisinde, internal juguler ven (IJV) ve/veya azigos venlerde venöz drenaj bozukluğu olarak tanımlanan kronik serebrospinal venöz yetmezliğin (KSSVY) etkili olduğu ileri sürülmektedir. Bu teori, MS etyopatogenezinde etkili olduğu düşünülen otoimmün teoriyi toptan yadsıması nedeni ile ciddi tartışmalar başlatmıştır. Bu teori ile, MS etyopatogenezine farklı açılardan bakılması nedeniyle ilgi çekmiş ve bununla ilgili birçok çalışma başlatılmıştır. Çalışmamızda Doppler sonografi (DS), kranial MR venografi (MRV) ve selektif venografi (SV) ile MS hastalarında KSSVY’nin varlığının tespiti, ekstrakraniyal-intrakraniyal venöz yapıların yapısal- fonksiyonel açıdan incelenmesi, sağlıklı kişilerle karşılaştırılması amaçlanmıştır. 25 Relapsing Remitting MS hastasına DS, SV ve kraniyal MRV yapılırken, 20 sağlıklı kişiye kraniyal MR venografi ve Doppler sonografi yapıldı. Hastalarda DS’ de reflü varlığı açısından kontrol grubuna göre istatistiksel olarak anlamlı idi (p

Anahtar Kelimeler:

Kronik serebrospinal venöz yetmezlik, multipl skleroz, serebral ven

Evaluation of Extracranial and Intracranial Venous Structures with Doppler Sonography, Cranial MR Venography and Selective Venography in Relapsing-Remitting Multiple Sclerosis Patients and Their Comparisons with Healthy Controls

Chronic cerebrospinal venous insufficiency (CCSVI), defined as impaired drainage at internal juguler vein (IJV) and/or azygos veins, has been accused of as an etiological factor in multiple sclerosis (MS) recently. This theory has initiated serious discussions due to negation of the autoimmune theory in MS. With this theory, MS etiopathogenesis has attracted attention due to its different perspectives and many studies have been started. A lot of studies are being conducted at many centers and conflicting results have been reported recently. We aimed to evaluate extracranial and intracranial venous structures by Doppler sonography (DS), cranial MR venography(MRV), and selective venography(SV) for the presence of CCSVI in MS patients and compare the results with healthy subjects. DS, SV and cranial MRV were performed in 25 relapsing-remitting MS patients´whereas cranial MRV and DS were performed in 20 healthy subjects. We found significantly more reflux in MS by DS than the control group (p

Keywords:

multiple sclerosis, cerebral veins, intra-extracranial veins,

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