Fibromiyaljili Hastalarda D vitamini Düzeyi Hastalık Şiddeti ve Enflamatuar Göstergeler ile İlişkili midir?

Bu çalışmada fibromiyalji hastalarının D vitamini seviyeleri ile hastalık şiddeti ve enflamasyonla ilişkisini nötrofil lenfosit oranı (N/L), platelet lenfosit oranı (P/L), ortalama trombosit hacmi (OTH), eritrosit sedimentasyon hızı (ESH) ve C-reaktif protein (CRP) parametrelerini kullanarak değerlendirme ve klinik önemini araştırma amaçlanmıştır. Çalışmaya SANKO Üniversitesi Uygulama ve Araştırma Hastanesi Fizik Tedavi ve Rehabilitasyon Polikliniğine başvurmuş fibromiyaljili hastalar ve sağlıklı kontroller dahil edildi. Fibromiyalji hastalarının fonksiyonel durumunu değerlendirmek için Fibromiyalji Etki Anketi kullanıldı. Hastalara ait demografik ve laboratuvar bilgileri retrospektif olarak dosya taraması ile elde edildi. Fibromiyalji (n=51) ve kontrol (n=46) grubu arasında cinsiyet ve yaş bakımından istatistiksel olarak anlamlı bir fark yoktu (sırasıyla; p=1.000, p=0.074). Hasta ve kontrol gruplarının trombosit, OTH, nötrofil, lenfosit, N/L, P/L değerleri arasında istatistiksel olarak anlamlı bir fark bulunamadı (p>0.05). Fibromiyalji hastalarında D vitamini eksikliği, CRP ve ESH düzeylerinde-ki yükseklik istatistiksel olarak anlamlı bulunurken (sırasıyla p<0.001, p=0.009, p=0.036), D vitamini eksikliği ve hastalık şiddeti arasında anlamlı bir korelasyon bulunamadı (p=0.313). Her iki grupta D vitamini ve hastalık şiddeti ile diğer parametreler arasında da istatistiksel olarak anlamlı bir korelasyon saptanmamıştır (p>0.05). Çalışmamız her iki grupta D vitamini eksikliğinin hastalık şiddeti ve trombosit, OTH, N/L, P/L, ESH, CRP değerleri arasında anlamlı bir ilişki olmadığını ortaya koydu. Fibromiyalji sendromunda D vitamini ile enflamasyon belirteçlerinin ve hastalık şiddetinin arasındaki ilişkiyi değerlendirmek için daha geniş çaplı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

fibromiyalji, D vitamini, enflamasyon

Is Vitamin D Level Related to Disease Severity and Inflammatory Indicators in Patients with Fibromyalgia

In this study, it is aimed to evaluate the relationship between vitamin D levels and disease severity and inflammation parameters using neu-trophil lymphocyte ratio (N/L), platelet lymphocyte ratio (P/L), mean platelet volume (MPV), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in fibromyalgia patients and to examine the clinical significance of it. Patients with fibromyalgia and healthy controls who applied to SANKO University Research and Application Hospital Physical Therapy and Rehabilitation Outpatient Clinic were included. The Fibromyalgia Impact Questionnaire was used to evaluate the functional status of patients with fibromyalgia. The demographic and laboratory data of the patients were retrospectively obtained. There was no statistically significant difference in age (p=1.000, p = 0.074) and in gender fibromyalgia (n=51) and controls (n=46). There was no statistically significant difference between patients with fibromyalgia and healthy controls in platelet, MPV, neutrophil, lymphocyte, N/L, P/L values (p>0.05). Vitamin D deficiency and high CRP and ESR levels was statistically significant in fibromyalgia patients (p<0.001, p=0.009, p=0.036, respectively), but no significant correlation was found between vitamin D and disease severity (p=0.313). There was no statistically significant correlation between vitamin D with other parameters in both groups (p>0.05). There was no significant relationship between vitamin D deficiency and disease severity and platelet, MPV, N/L, P/L, ESR, CRP values of in both groups. Larger studies are needed to evaluate the relationship between vitamin D and inflammation markers and disease severity in fibromyalgia syndrome.

Keywords:

Fibromyalgia, Vitamin D, Inflammation,

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