Hatice Nur ŞEFLEK, Fatma Zehra ERBAYRAM, Esma MENEVŞE

Erkek İnfertilitesinde Güncel Semen Biyobelirteçleri

İnfertiliteden etkilenen çiftler giderek artmaktadır. Erkek infertilite değerlendirilmesinde ilk adım, semen analizidir. Ancak seminal kompozisyon çevresel faktörlerden ve diğer patolojik durumlardan etkilendiği için erkek infertilite tanısında kesin bir sonuç vermediği durumlar söz konusudur. Bu nedenledir ki, erkek infertilitesinin tanısı veya tedavisi sürecinde farklı disiplinlerin araştırdığı diagnostik ve prognostik testlere ihtiyaç duyulmakta ve son yıllarda artan ivme ile çalışmalar devam etmektedir. Seminal plazma sıklıkla biyoloji alanının fertilizasyon durumunun değerlendirilmesinde tercih ettiği numune tipidir. Seminal plazmada kolay analiz edilebilen, biyokimyasal açıdan test duyarlılığı ve özgüllüğü yüksek biyobelirteçlerin belirlenmesi ve tanımlanmasının spermiyogram analizlerine ilaveten tanı ve tedavide infertil erkeklerin daha iyi tanımlanmasında bir yöntem olarak kullanılabilir. Dolayısıyla seminal plazma biyobelirteçleri ilerleyen zamanlarda erkek faktörlü infertilitenin değerlendirilmesinde ön analizlerden olacak gibi görünmektedir. Güncel çalışmalar seminal plazma biyobelirteçlerinin, azospermi vakalarında invaziv testis biyopsisine ek olarak yapılabileceğini ve hatta bazı belirteçlerin öncelikli olarak tercih edilebileceğini göstermektedir. Bununla birlikte, obstrüktif ve non-obstrüktif azospermi ayrımının yapılabildiği bildirilmektedir. Bununla birlikte, infertil erkek bireylerde yakın gelecekte spermiyogram analizlerinin yanında diagnostik ve prognostik biyobelirteçlerin biyokimyasal rollerini ve analizlerinin önemini vurgulamak üzere planlanan bu derlemenin literatüre katkı sağlayacağını düşünmekteyiz.

Anahtar Kelimeler:

Erkek infertilitesi, Semen proteomik, TEX-101, SPTRX-3, MDA

Current Semen Biomarkers in Male Infertility

The number of couples affected by infertility is increasing. The first step in male infertility is semen analysis. However, since the seminal composition is affected by environmental factors and other pathological conditions, there are cases where it does not give a definite result in the diagnosis of male infertility. For this reason, diagnostic and prognostic tests investigated by different disciplines are needed in the diagnosis or treatment of male infertility, and studies have continued with increasing note in recent years. Seminal plasma is often the type of sample preferred by biology field in the evaluation of fertilization status. In addition to spermiogram analysis to determine and identificate the biomarkers that can be easily analyzed in seminal plasma, and have high biochemical test sensitivity and specificity can be used as a method for better identification of infertile men in their diagnosis and treatments. Therefore, seminal plasma biomarkers seem to be one of the preliminary analyzes in the evaluation of male factor infertility in the future. Recent studies show that seminal plasma biomarkers can be performed in addition to invasive testicular biopsy in cases of azoospermia, and even some markers may be preferred as a priority. However, it is reported that it is possible to distinguish between obstructive and non-obstructive azoospermia. However, we think that this review, which is planned to emphasize the importance of biochemical roles and analyzes of diagnostic and prognostic biomarkers in addition to spermiogram analyzes in infertile male individuals in the near future, will contribute to the literature.

Keywords:

Male infertility, Semen proteomıc, TEX-101, SPTRX-3, MDA,

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