Doksorubisin ile İndüklenmiş Ovaryan Toksisitede Visnaginin Koruyucu Etkisi

Doksorubisine bağlı ovaryan toksisitede ovaryan rezervi korumak amacıyla farklı tedavi yaklaşımları uygulanmaktadır. Visnagin doksorubisine bağlı kardiyotoksisitede tedavi edici etkinliği gösterilmiş organik bir kimyasaldır. Bununla birlikte doksorubisine bağlı ovaryan toksisitede visnaginin etkinliği bilinmemektedir. Doksorubisine bağlı ovaryan toksisitenin oluşturulduğu sıçanlarda visnaginin tedavi edici etkinliğini değerlendiren bu çalışmada; doksorubisinin ovaryan rezervi belirleyen primordiyal follikül sayısını, bunun yanında preantral ve antral follikül sayısını azalttığı saptandı. İntraperitoneal 30 mg/kg visnagin tedavisinin primordiyal follikül rezervini, gelişmekte olan ve olgun follikül sayılarını koruduğu, atretik follikül sayısını azalttığı görüldü. Doksorubisin ile indüklenmiş ovaryan toksisitenin visnagin tedavisi ile azaltıldığı ve ovaryan follikül rezervini koruduğu sonucuna varıldı.

Anahtar Kelimeler:

Doksorubisin, Visnagin, Ovaryan Toksisite

Protective Effect of Visnagin on Doxorubicin-Induced Ovarian Toxicity

Different treatment approaches are used to for preserve ovarian reserve in ovarian toxicity due to doxorubicin. Visnagin is an organic chemical that shows therapeutic activity on doxorubicin-induced cardiotoxicity. However, the efficacy of visnagin on ovarian toxicity due to doxorubicin is unknown. In this study evaluating the therapeutic effect of visnagin in rats with ovarian toxicity induced by doxorubicin, it was determined that doxorubicin decreased the number of primordial follicles that determined ovarian reserve, as well as the number of preantral and antral follicles. Intraperitoneal administration of 30 mg/kg of visnagin treatment decreased the number of atretic follicles and preserved primordial, developing and mature follicle counts. As a result, it was concluded that ovarian toxicity induced by doxorubicin was reduced with visnagin treatment and the visnagin treatment preserved of ovarian follicle reserve.

Keywords:

Doxorubicin, Visnagin, Ovarian toxicity,

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