Büşra YÜCEL, Arzu ALA GÖRMEZ

9418

SARS-Corona Virüsüne Genel Bakış

Sars-Corona Virüsü (SARS-CoV), Mart 2003 yılında ilk kez Çin’de görülen ve şiddetli akut solunum yetmezliğine neden olan bir koronavirüstür. İnsanlarda enfeksiyonlara neden olan korona virüsler Alfa ve Beta korona virüs cinsleri içerisinde yer almakta ve özellikle hayvanlardan insanlara bulaşarak, enfekte ettiği kişilerde yüksek ateş, öksürük, kas ağrısı, ishal, zor nefes alma şeklinde semptomlara neden olmaktadır. Virüs özellikle yakın temas sonucunda epidemik salgınlar oluşturabilmektedir. Bu nedenle enfeksiyondan korunmak için koruyucu tedbirler büyük önem arz etmektedir. SARS-CoV insan ve hayvanlarda epitel hücreler, lökositler ve tümör hücreleri gibi çeşitli dokularda bulunan ve hücre yüzeyinde sergilenen bir adhezyon molekülü olarak bilinen CEACAM1 (Carcino embryonic antigen-related cell adhesion molecule 1) reseptörlerine bağlanarak hücreye giriş yapmakta ve akabinde hücre içerisinde S (Spike), E (Zarf) , M (Membran), N (Nükleokapsid) gibi yapısal proteinleri ve yardımcı proteinleri aracılığıyla yeni virüs partikülleri oluşturulmaktadır. Konak hücre içerisinde oluşturulan virüs, ekzositoz yoluyla konakçıdan dışarı salınarak yeni enfeksiyonlara neden olmaktadır. Virüsün teşhisinde çeşitli immünolojik testler ve spesifik genleri hedef alarak yapılan PCR çalışmaları büyük önem arz etmektedir. Son yıllarda SARS-CoV salgınları görülmediğinden tedavi amaçlı spesifik ilaçlar ve aşılar ile ilgili çalışmalar azalsa da virüs salgınlarının yeniden oluşabileceği göz önüne alınarak ihmal edilmemesi gerekmektedir.
Anahtar Kelimeler:

SARS-CoV, epidemi, patogenez

SARS-Corona Virus Overview

Sars-Corona Virus (SARS-CoV) is a coronavirus that was first seen inChina in February 2003 and causes severe acute respiratory failure.Corona viruses that cause infections in humans are found in Alfa and Betacorona viruses and cause symptoms such as high fever, cough, muscleaches, diarrhea and difficult breathing in infected people, especially wheninfected by animals. The virus can create epidemic outbreaks, especiallyas a result of close contact and for this reason, it is of great importance totake preventive precautions to protect against infectious diseases.Especially close contact with the virus can lead to epidemic outbreaks,and protective measures are therefore of great importance to protectagainst infections. SARS-CoV enters cells by binding to CEACAM1(carcino embryonic antigen-related cell adhesion molecule 1) receptorsknown as an adhesion molecule displayed in various tissues such asepithelial cells, leukocytes and tumor cells in humans and animals andthen new virus particles are formed by helper proteins and structuralproteins such as S (Spike), E (Envelope), M (Membrane), N(Nucleocapsid) in the cell. Virus formed in the host cell is released fromthe host via exocytosis, causing new infections. In the diagnosis of thevirus, various immunological tests and PCR studies targeting specificgenes are of great importance. Since SARS-CoV outbreaks have not beenobserved in recent years, studies on specific medicines and vaccines fortreatment should not be avoided, even though virus epidemics may recur.
Keywords:

SARS-CoV Epidemic, Patogenesis, ORF,

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Türkiye Teknoloji ve Uygulamalı Bilimler Dergisi-Cover
  • ISSN: 2528-8652
  • Başlangıç: 2017
  • Yayıncı: Siirt Üniversitesi
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