In this study, the gradual prohibition of interest (riba) in the Holy Qur’an, reasons, the specific language and wording, and outcomes are discussed. Prohibition of interest in Qur’an became gradually true as it happened in some other issues. In fact, there exist thirteen verses in total regarding the issue of interest in the Holy Qur’an. Three of them are the verses which recommend Muslims not to end up like others instead of prohibiting interest strictly by decrying the usage of interest, rather advising zakat, and expressing the disasters that Jews had experienced since they violated this rule in the past. On the other hand, the other ten verses prohibit interest strictly and were revealed later towards the end of revelation. Moreover, it is a widely known narration that the verses regarding interest in surah al-Baqarah were revealed in the last days of revelation. Some of the verses prohibiting interest, directly declare the ban while others are related to awards and sanctions as a kind of remuneration for following or not following the commands. Some of the important characteristics of the verses prohibiting interest are as follows: Following a gradual course in terms of time, extension of the prohibition of an old practice over a period of time, that the revelation of the prohibited verses occurred towards the end of revelation, that the language used is very harsh compared to other practical prohibitions, and that the sanctions for violators are valid for both this world and the hereafter. The reason is that the use of interest has significantly been differentiated from other prohibitions by plugging the issue into the obedience to Allah and his Prophet as well as considering the subject as a matter of faith in Islam. The Holy Qur’an states this reasoning as “… that is because they say: ‘Trade is like usury’ But Allah has permitted trade and forbidden usury…” in surah al-Baqarah (275).