Schwannoma’larda farklı morfolojik ve immun dokukimyasal özellikler ile osseöz metaplazi gösteren bir olgunun sunumu

Amaç: Elli yaşındaki erkek hastanın schwannoma tanısı alan spinal kitlesinin kesitlerinde fokal osseöz metaplazi saptanması üzerine, schwannoma olgularımızın histomorfolojik ve immündokukimyasal özelliklerinin retrospektif olarak incelenmesi amaçlanmıştır. Yöntem: 2002-2005 yılları arasında Karaelmas of schwannoma retrospectively Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı’nda tanı almış dokuz schwannoma olgusunun preparatları Methods
Anahtar Kelimeler:

Schwannoma, osseöz metaplazi

Distinct morphological and immunohistochemical features in schwannomas and report of a case with osseous metaplasia

Background: The sections from a thoracolomber mass

___

  • Ackerman’s Surgical Pathology, 9th edition. Edinburgh:
  • Mosby; 2004. p. 2237-371. 2. Weiss SW, Goldblum JR. Benign tumors of peripheral
  • nerves. In: Weiss SW, Goldblum JR, editors. Enzinger and
  • Weiss’s soft tissue tumors. 4th edition. St. Louis, Missouri:
  • Mosby; 2001. p.1111-1207. 3. Canda MŞ. Periferik sinir kılıfı tümörleri. Tr Ekopatol Derg
  • 2004; 10: 65-74. 4. Weiss SW, Goldblum JR. Malignant tumors of the
  • peripheral nerves. In: Weiss SW, Goldblum JR, editors.
  • Enzinger and Weiss’s soft tissue tumors. 4th edition. St.
  • Louis, Missouri: Mosby; 2001. p.1209-63. 5. Yamamoto T, Minami R, Ohbayashi C. Subcutaneous
  • malignant epithelioid schwannoma with cartilaginous
  • differentiation. J Cutan Pathol 2001; 28: 486-91. 6. Chang SM, Ho WL. Malignant peripheral nerve sheath
  • tumor: a study of 21 cases. Zhonghua Yi Xue Za Zhi
  • (Taipei) 1994; 54: 122-30. 7. Li Y, Yang H, Li G. Epithelioid variant of malignant peripheral nerve sheath tumor. Zhonghua Bing Li Xue Za
  • Zhi 1996; 25: 355-57. 8. Yılmaz F, Uzunlar AK, Bükte Y, Özekinci S, et al. Primary
  • malignant schwannoma of the small bowel. Turk J Med Sci
  • 2001; 31: 459-61. 9. Grayson W, Hale MJ. Epithelioid psammomatous melanotic
  • schwannoma with osseous metaplasia. Arch Pathol Lab
  • Med 1998; 122: 285-87. 10. Kasantikul V, Brown WJ, Netsky MG. Mesenchymal
  • differentiation in trigeminal neurilemmoma. Cancer 1982; 50: 1568-71. 11. Fanburg-Smith JC, Majidi M, Miettinen M. Keratin
  • expression in schwannoma: a study of 115 retroperitoneal
  • and 22 peripheral schwannomas. Mod Pathol 2006; 19: 115-21. 12. Gray MH, Rosenberg AE, Dickersin GR, Bhan AK. Glial
  • fibrillary acidic protein and keratin expression by benign
  • and malignant nevre sheath tumors. Hum Pathol 1989; 20: 1089-96. 13. Miettinen M. Melanotic schwannoma coexpression of
  • vimentin and glial fibrillary acidic protein. Ultrastruct Pathol
  • 1987; 11: 39-46. 14. Memoli VA, Brown EF, Gould VE. Glial fibrillary acidic
  • protein (GFAP) immunoreactivity in peripheral nevre sheath
  • tumors. Ultrastruct Pathol 1984; 7: 269-75. 15. Kawahara E, Oda Y, Ooi A, Katsuda S, et al. Expression of
  • glial fibrillary acidic protein (GFAP) in peripheral nevre
  • sheath tumors. A comparative study of immunoreactivity of
  • GFAP, vimentin, S-100 protein, and neurofilament in 38
  • schwannomas and 18 neurofibromas. Am J Surg Pathol
  • 1988; 12: 115-20. 16. Zhang HY, Yang GH, Chen HJ, Wei B, et al. Clinico- pathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J
  • (Engl) 2005; 118: 1451-61. 17. Yasuda T, Sobue G, Ito T, Doyu M, et al. Human peripheral
  • nevre sheath neoplasm: expression of Schwann cell-related
  • markers and their relation to malignant transformation. Muscle
  • Nerve 1991; 14: 812-19. 18. Utermark T, Schubert JAS, Hanemann OC. Rearran
  • gements of the intermediate filament GFAP in primary
  • human schwannoma cells. Neurobiol Dis 2005; 19:1-9. 19. Gould VE, Moll R, Moll I, Lee I, et al. The intermediate
  • filament complement of the spectrum of nevre sheath
  • neoplasms. Lab Invest 1986; 55: 463-74. 20. Canda MŞ, Kırımca F, Gökden N, Pabuççuoğlu HU. Spinal
  • Schwannomanın patolojisi (7 olgu). Tr Ekopatol Derg 1997; 3: 35-36. 21. Daimaru Y, Hashimoto H, Enjoji M. Malignant peripheral
  • nevre-sheath tumors (malignant schwannomas) An
  • immunohistochemical study of 29 cases. Am J Surg Pathol
  • 1985; 9: 434-44. 22. Özel E, Peşterelli HE, Şimşek T, Karaveli FŞ, et al.
  • Malignant peripheral nerve sheath tumor of the vulva: A
  • case report. Turkish Journal of Cancer 2006; 36: 31-34.