Vitamin B12 Eksikliği Olan Çocuk Hastalarda Böbrek Fonksiyon Parametrelerinin Değerlendirilmesi

Amaç: Vitamin B12, hücre metabolizması, deoksiribo nükleik asit sentezi, hücre proliferasyonu için yaşamsal öneme sahiptir. Vitamin B12 eksikliğinde nörolojik ve hematolojik sistemin etkilendiği bilinmektedir. Bu çalışmada da, vitamin B12 eksikliğinin böbrek fonksiyonları üzerine etkisinin incelenmesi amaçlandı. Gereç ve Yöntemler: Vitamin B12 eksikliği olan 34, yaş ve cinsiyet özellikleri açısından benzer özellikler gösteren 36 sağlıklı çocuk çalışmaya dahil edildi. Hastalara ait tam kan sayımı, serum üre, kreatinin, vitamin B12, holotranskobalamin, metil malonik asit, homosistein, ferritin, folat düzeyleri ve tahmini glomerüler filtrasyon hızı kaydedildi. Ayrıca, idrarda protein, mikroalbumin ve nötrofil jelatinaz ilişkili lipokalin değerleri ölçüldü. Bulgular: Çalışmaya katılan çocukların böbrek fonksiyonlarını gösteren parametreler normal değerlerdeydi. Böbrek fonksiyonları ile ilgili parametreler açısından vitamin B12 eksikliği olan ve olmayan hastalar arasında anlamlı fark yoktu. Her iki grup arasında vitamin B12 ve nötrofil jelatinaz ilişkili lipokalin arasında korelasyon bulunmadı, ama holotranskobalamin ve nötrofil jelatinaz ilişkili lipokalin arasında negatif korelasyon saptandı (r =-0.24, p =0.045). Holotranskobalamin vitamin B12 eksikliği olan grupta anlamlı derecede düşüktü (p<0.001). Sonuç: Anemisi olmayan çocuklarda vitamin B12 eksikliğinin böbrek fonksiyonları üzerine belirgin olumsuz etkisi bulunamamıştır.

Anahtar Kelimeler:

children, vitamin B12 deficiency, uNGAL, kidney function, holotranscobalamin

Evaluation of Kidney Function Parameters in Children with Vitamin B12 Deficiency

Objective: Vitamin B12 is crucial for cell metabolism, deoxyribonucleic acid synthesis and cell proliferation. Hematological and neurological systems are known to be affected in vitamin B12 deficiency. The aim of this study was to research the effects of vitamin B12 deficiency on kidney function parameters. Material and Methods: Thirty-four children with vitamin B12 deficiency and 36 sex and age-matched healthy controls were included in the study. Complete blood count, serum urea, creatinin, vitamin B12, holotranscobalamin, methyl malonic acid, homocysteine, ferritin, folate and estimated glomerular filtration rate were recorded. Additionally, spot urine protein, microalbumin and neutrophil gelatinase-associated lipocalin were measured. Results: Kidney function parameters were normal for childrens that participated the study. Serum kidney function parameters adjusted for age also showed no significant difference between the two groups. No correlation was found between serum vitamin B12 and neutrophil gelatinase-associated lipocalin; however, a negative correlation was detected between neutrophil gelatinase-associated lipocalin and holotranscobalamin (r =-0.24, p =0.045). Holotranscobalamin was substantially lower in the group with vitamin B12 deficiency (p<0.001). Conclusion: No negative influence of B12 deficiency on kidney function was found in non-anemic children.

Keywords:

Child, Holotranscobalamin, Kidney function, Vitamin B12 deficiency,

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