Ali BAY, Serdar ÖZKASAP, Pamir IŞIK, Abdurrahman KARA, Neşe YARALI, Bahattin TUNÇ, Ayhan YAMAN

Vinkristin İlişkili Geç Kraniyal Polinöropati: Olgu Sunumu

Burada 8 aylık bir çocukta piridoksin ve piridostigmin tedavisi ile düzenlenen vinkristin ilişkili bir kraniyal polinöropati olgusunu sunduk. 8 aylık kız hastada pre B cell ALL tanısı kondu. Hastaya ALL St Jude TXIII tedavi protokolü başlandı. Dördüncü vinkristin dozunda 20 gün sonra pitozis gelişti. Nörolojik muayenede pupiller ve korneal refleksler normaldi. Pitozis gelişmeden önce total 2.8 mg vinkristin almıştı. Nöroprotektif ve nörorejenaratif tedavi olarak piridoksin ve piridostigmin başlandı. Pitozis 6 gün içinde düzelmeye başladı ve 2 hafta içinde tamamen iyileşti. Tedavi 3haftaya tamamlandı ve herhangi bir yan etki görülmedi. Takipte pitozis tekrar etmedi.

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VINCRISTINE INDUCED LATE CRANİAL POLYNEUROPATHY: CASE REPORT

İn this poper we described an 8-month-old girl with vincristine induced cranial polyneuropathy who was succesfully treated with pyridoxine and pyridostigmine. The patient was diagnosed as preB cell ALL and received chemotherapy according to the previously described St. Jude total therapy XIII studies. Twenty days after the fourth dose of vincristine (cumulative dose 2.8 mg), she developed ptosis. Neurological examination revealed ptosis with normal pupillary and corneal reflexes. Pyridoxine and pyridostigmine was initiated as an attempt for neuroprotection and neuroregeneration. Ptosis markedly improved after 6 days and completely resolved after two weeks. Both agents were given for 3 weeks and were well tolerated without any side effects. During the follow up period we did not observe residue recurrence of ptosis

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