Ergun ÇETİNKAYA, Ayşe Esin KİBAR, Zehra AYCAN, Sadi VİDİNLİSAN, Bahar ÇAKIR, Belkıs GÖKDAĞ, Fatih GÜRBÜZ
Tip 1 Diabetes Mellitus’ta İnsulin Glargin Tedavisine Geçişin Hipoglisemik Ataklara ve Hemoglobin AC Düzeylerine Etkisi
Amaç: Bu çalışmada Tip 1 Diabetes Mellituslu çocuklarda insülin glargin (Lantus®) tedavisinin etkinliğini, hipoglisemi açısından güvenilirliğini göstermeyi ve ülkemizdeki verileri tartışmayı amaçladık.Materyal ve Metod: Altı ay önce insülin glargin tedavisine geçilen 12'si erkek 13'ü kız, 25 Tip 1 diabetik hastanın verileri retrospektif olarak analiz edildi.Bulgular: İnsülin glargin tedavisinin önce ve sonrasındaki ortalama HbA1c düzeyleri % 9.2±1.7 ve % 8.1±1.4 idi (p<0,05). On sekiz hastanın tedaviye cevabı HbA1c düzeyinde % 1.8±1.1 düşüş şeklinde iken, kalan 7 hastada da % 0.6±0.5 yükselme saptandı. Hipoglisemik epizodlara bakıldığında ise gece hipoglisemileri açısından belirgin istatistiksel fark bulunamadı ancak hipoglisemik epizodların sayısı (% 65) ayda 7.7±7.3'den 5.5±6.9' a geriledi (p<0,05).Sonuç: Tip 1 Diabetes Mellituslu çocuklar ve genç erişkinlerde insülin glargin tedavisinin hipoglisemik atakları arttırmadan glisemik kontrolü sağladığı gözlendi.
Anahtar Kelimeler:
Tip 1 diabet, insülin glargin, hipoglisemi
TİP 1 DİABETES MELLİTUS’TA İNSULİN GLARGİN TEDAVİSİNE GEÇİŞİN HİPOGLİSEMİK ATAKLARA ve HEMOGLOBİN A C DÜZEYLERİNE ETKİSİ
Aim: We aimed to determine the safety and efficacy of insulin glargine(Lantus®) in Type 1 diabetic patients and to present our country's data on this issue.Material and Methods: Retrospective chart analysis is performed on 25 Type 1 diabetic patients (12 male, 13 female) 6 months after switching to insulin glargine (IG) therapy.Results: Mean HbA c levels before and after IG therapy were 9.2±1.7 % and 8.1±1.4% respectively (p<0,05). Eighteen patients' response (% 72) were a decrease in HbA c levels by 1.8±1.1%; whereas the remaining 7 patients' response to insulin glargine therapy were a rise of 0.6±0.5 %. When the number of hypoglycemic episodes were analysed; we observed that there were no statistically significiant difference in nocturnal hypoglycemic episodes but severe hypoglycemic episodes (% 65) decreased from 7.7±7.3 to 5.5±6.9 episodes/month (p<0,05).Conclusion: Insulin glargine treatment improved gylcemic control in children and adolescents with type 1 diabetes without increasing hypoglycemic episodes
Keywords:
Type 1 diabetes , insulin glargine, hypoglycemia,
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- ISSN: 1307-4490
- Başlangıç: 2007
- Yayıncı: -