Tekrarlayan Bronşioliti/Hışıltısı Olan Okul Öncesi Çocuklarda İmmünglobulin Düzeylerinin Hışıltı Fenotiplerine Göre Değerlendirilmesi

Amaç: Tekrarlayan bronşiolit/hışıltı okul öncesi dönemde sık görülmektedir. Epizodik hışıltı ve çoklu tetikleyici hışıltıfenotipleri tanımlanmıştır. Çalışmamızın amacı, epizodik hışıltı (EH) ve çoklu tetikleyici hışıltısı (ÇTH) olan çocuklarınimmünglobulin düzeylerinde fark olup olmadığını belirlemektir.Gereç ve Yöntemler: Tekrarlayan bronşiolit/hışıltısı olan 4 yaş altındaki son bir yılda en az 3 bronşiolit/hışıltı atağıgeçirmiş olan çocuklar çalışmaya alındı. Hastalar fenotiplere göre epizodik ve çoklu tetikleyici hışıltı olarak iki gruptaincelendi. Eozinofil sayısı, eozinofil yüzdesi, immünglobulin (Ig) A, G, M düzeyleri kayıt edildi.Bulgular: Tekrarlayan bronşioliti/hışıltısı olan 86 çocuk (55 erkek, 31 kız) çalışmaya alındı. IgA düzeyi EH (43.3±35 mg/dl) olan grupta ÇTH grubuna (74.1±45.1 mg/dl) göre daha düşük bulundu (p

Evaluation of Immunoglobulin Levels According to Wheezing Phenotypes in Preschool Children With Recurrent Wheezing/ Bronchiolitis

Objective: Recurrent bronchiolitis/wheeze is frequent in preschool children. Episodic viral wheeze (EVW) and mutitrigger wheezing (MTW) phenotypes have been described. Our aim was to evaluate whether immunoglobulin levels differ in children with episodic and multitrigger wheezing. Material and Methods: Children ≤4 years of age with the history of at least three episodes of acute bronchiolitis/ wheeze during the last 12 months included in study. Patients were evaluated according to wheezing phenotypes as episodic and multi-trigger wheezing. Eosinophil count, eosinophil %, IgA, G, M levels were recorded. Results: 86 (55 male, 31 female) children with recurrent bronchiolitits were included in study. IgA levels in EVW group (43.3±35 mg/dl) were found lower than MTW group (74.1±45.1) (p

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