Çölyak Hastalığı

Çölyak hastalığı (ÇH) oldukça sık görülen bir hastalıktır. Klasik ÇH küçük yaşlarda ortaya çıkarken, atipik hastalık büyük çocuklarda ortaya çıkma eğilimindedir. Değişik klinik bulgular ve tanı- tarama yöntemleri hakkındaki bilgi birikimin artması hastalıktan etkilenen çocukların erken tanı almasına ve uygun müdahalesine olanak sağlamıştır. Serolojik testler daha güvenilir hale gelmesine rağmen, özellikle 2 yaş altındaki çocuklarda testlerle ilgili sorunlar devam etmektedir. Çölyak hastalarının büyük bir kısmı HLA DQ2 veya DQ8 kodlayan genleri taşırlar. Bu genlerin negatifliği ÇH olasılığını dışlamak için yararlı olabilir. Çölyak hastalığına tanı koymak için Glutensiz diyet başlanmadan önce, gluten içeren diyet altında duodenal biyopsi yapılmalıdır. Glutensiz diyet asemptomatik olan hastalar da dahil ÇH tanısı alan tüm çocuklara verilmelidir.

Anahtar Kelimeler:

Çocuk, Çölyak hastalığı

Celiac Disease

Celiac disease is extremely common. The classical presentation tends to occur in younger children, while atypical presentations occur at an older age. Knowledge about the varied clinical manifestations together with CD screening and diagnosis lead to appropriate early diagnosis and intervention in affected children. Although serologic testing has become more reliable, there still remain significant problems with testing, particularly in children under 2 years old. Genes encoding HLA DQ2 or DQ8 are found in the vast majority of those with CD, and negative test results can be useful in ruling out the disorder. All patients should undergo a duodenal biopsy while on a gluten-containing diet in order to diagnose CD before a gluten-free diet (GFD) is recommended. A GFD should be offered to all children diagnosed with CD even when perceived as asymptomatic

Keywords:

Child, Celiac disease,

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