Bronkopulmoner Displazide İnhale Kortikosteroid Kullanımı

Bronkopulmoner displazi, preterm bebeklerde alveoler gelişimde duraksama ve akciğer hasarına bağlı gelişen kronik bir akciğer sorunudur. Bronkopulmoner displazi gelişiminde mekanik ventilasyonun neden olduğu travma, oksijen toksisitesi, azalmış surfaktan üretimi, enfeksiyon ve inflamasyon rol oynamaktadır. Primer mediatör olan inflamatuvar sürecin durdurulması için sistemik ve inhale kortikosteroidler kullanılmaktadır. Bu yazıda, bronkopulmoner displazinin önlenmesinde ve tedavisinde kullanılan inhale kortikosteroidler gözden geçirilerek son önerilere yer verilmiştir.

Anahtar Kelimeler:

Bronkopulmoner displazi, inhale steroid, yenidoğan

Use of Inhaled Corticosteroids in Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia is a chronic lung problem caused by pause and lung damage in alveolar development in preterm infants. Trauma caused by mechanical ventilation, oxygen toxicity, decreased surfactant production, infection and inflammation play a role in the development of bronchopulmonary dysplasia. Systemic and inhaled steroids are used to stop the inflammatory process, which is the primary mediator. Herein, inhaled steroids used in the prevention and treatment of bronchopulmonary dysplasia are reviewed and recent recommendations are given.

Keywords:

Bronchopulmonary dysplasia, inhaled corticosteroids, newborn,

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