Astımlı Çocuklarda İnfluenza Aşısı İle Hastalık Kontrolü Arasındaki İlişkinin Belirlenmesi

Amaç: İnfluenza aşısının astım kontrolü üzerindeki etkisi tartışmalıdır. Bu çalışmanın amacı astımlı çocuklarda influenza aşısının hastalık kontrolüne etkisini araştırmaktır. Gereç ve Yöntemler: Astım tanısı alan çocuklar prospektif olarak çalışmaya dahil edildi. Hastaların sosyo-demografik özellikleri, bir önceki yılda influenza aşısı olma durumu, bronkodilatatör kullanımı ve sistemik steroid tedavisi, hastaneye yatış sıklığı, aşılam durumunu ve hastalığın kontrol durumunu etkileyecek risk faktörleri araştırıldı. Bulgular: Çalışmaya ortanca yaşı 11 olan toplam 187 astımlı çocuk dahil edildi. Hastaların yaklaşık yarısında (%47,6) astım kontrol altında değildi. Son bir yılda %14,4'ü, %14,4'ü iki, %19,3'ü ≥3 atağı geçirirken, %51,9'u astım atağı geçirmedi. Bir önceki yılda hastaların %52,4'ü grip aşısı olmuştu. İnfluenza aşılaması, kontrollü ve kontrolsüz astımı olan hastalarda eşit oranda yaygındı (%54.1'e karşı %50.6) ve aşılamanın hastalık kontrolü üzerinde etkisi yoktu (p=0.662). Alerjik riniti ve atopisi olan hastalarda, alerjik riniti olmayan hastalara göre anlamlı olarak daha yüksek kontrolsüz astım durumu vardı (sırasıyla p=0.027 ve p=0.041). Kontrolsüz astımı olan çocuklar kontrol grubuna göre daha az profilaktik ilaç kullanmışlardı (p<0.001). Sonuç: İnfluenza aşısının astımlı çocuklarda hastalık kontrolüne etkisi yoktur. Alerjik rinit ve atopiye sahip olmak hastalığın kontrolünü azaltır.

Anahtar Kelimeler:

astım, allerjik rinit, çocuk, influenza

Determining The Relationship Between Influenza Vaccination and Disease Control in Children with Asthma

Objective: The influenza vaccine's effect on the control of asthma is debatable. The purpose of this study is to investigate the effect of the influenza vaccine on disease control in children with asthma. Material and Methods: Children with a diagnosis of asthma were prospectively included in the study. The socio-demographic characteristics of the patients, the status of influenza vaccination in the previous year, the use of bronchodilators and systemic steroid therapy, the frequency of hospitalization, risk factors that will affect the disease's control status, and the effects of vaccination status and risk factors on the control of the disease were investigated. Results: A total of 187 asthmatic children with a median age of 11 years were included in the study. Almost half of the patients (47.6%) did not have asthma under control. In the last year, 14.4% had one asthma attack, 14.4% had two attacks, 19.3% had ≥3 attacks, while 51.9% had no asthma attack. In the previous year, 52.4% of patients received influenza vaccination. Influenza vaccination was equally common in patients with controlled and uncontrolled asthma (54.1% vs 50.6%), and vaccination had no effect on disease control (p=0.662). Patients with allergic rhinitis and atopy had significantly higher uncontrolled asthma status than patients without allergic rhinitis (p=0.027 and p=0.041, respectively). Children with uncontrolled asthma used less prophylactic drugs than those in control (p<0.001). Conclusion: The influenza vaccine has no effect on disease control in children with asthma. Having allergic rhinitis and atopy reduces the control of the disease.

Keywords:

asthma allergic rhinitis, child, influenza, vaccine,

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