The study aimed at investigates the science students’ satisfaction level of using e-learning and virtual classes in exceptional condition COVID-19 Crisis, in light of three demographic variables: students’ specialization, educational level, and GPA. The population consisted of all science students (Physics, Chemistry, Biology, and Mathematics) in the college of science at a university from Eastern Province, Saudi Arabia. The sample comprised of 116 science students. The researcher developed a questionnaire and verified its validity and reliability for collecting data. Some statistical analyses such as mean, standard deviations, and ANOVA tests were conducted to analyze the questionnaire. The results indicated that the satisfaction level of using e-learning and virtual classes by science students is medium in general but with varying degrees from one item to another. The results did not show significant statistical differences at the level (α = 0.05) of the use of e-learning and virtual classes for all independent variables: students’ specialization, educational level, and GPA. The study included several recommendations; the most important of which is the necessity of providing infrastructure in the university (all colleges) concerning e-learning and educational technology, providing training programs for all university professors and students on how to use e-learning efficiently to boost their competences and skills in utilizing these innovative models.