Aims: In this study, the relation between the regulator and counter-regulator systems of blood sugar which were impaired in heavy infection cases, the negative effects of defence and healing mechanisms of the body and the patient mortality has been studied.Methods: 30 patients (19 males, 11 females) with severe infection (sepsis) have been scanned retrospectively. Patient data has been gathered in one common database and stratification has been made in relation to fasting blood glucose, CRP and APACHE-II rates.Results: There is a statistically significant relationship between the high blood sugar levels of the patients and their increased CRP levels. It has been determined that blood sugar levels between 105 – 145 mg/dl provides optimal patient survival.Conclusion: Glycaemic regulation is impaired in sepsis patients. Keeping the blood glucose levels in physiologic ranges is an important factor to be considered regarding patient survival