Dear readers, I would like to present to you TMSJ’s June issue of 2021. In this issue, you will find 11 articles: consisting of 1 editorial, 3 reviews, 4 original articles, and 3 case reports. Below you can find quick synopses for these articles. Having discussed its distinct and precise anatomy, it is essential to know the variations that might lead to pathologies. Besides its anat- omy, various pathological cases should be kept in mind, essentially for surgical interventions and postoperative follow-ups. Successful sur- gery without incurring significant neurovascular morbidity in this region depends on the detailed knowledge of its vascular anatomy and pathologies. Therefore, Ersoy et al. describe anterior cerebral circulation in a literature review. Şenödeyici et al. aim to discuss the historical development, working mechanisms, present and future clinical applications of zinc-finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced short palindromic repeats, and prime editors, while presenting the ethical aspects of using these genomes editing tools. Ersoy et al. illustrate iron metabolism in the human body and its pathophysiology during heart failure and give a comprehensive overview of the studies and trials investigating the role of iron in heart failure.