Fatih Erkan AKAY, Hakkı Onur KIRKIZLAR, Elif MERCAN, Fulya ÖZ PUYAN

CLINICOPATHOLOGICAL FEATURES OF MYELOID SARCOMA PATIENTS FROM A SINGLE CENTER EXPERIENCE

Aims: This retrospective study aims to emphasize clinicopathological data and diagnosis of an uncommon myeloid neoplasm; myeloid sarcoma. Methods: Data of all patients from 2000-2019 were retrieved from the archives of Trakya University School of Medicine Hematology and Pathology Departments. Patients’ charts were examined retrospectively by collecting data including age, gender, anatomic site, history of hematological malignancy, blood count, pathological characteristics and treatments administered. Results: There were 8 patients; 6 male and 2 female. The median age was 42.5 years (range: 29-69 years). The most prevalently involved sites were skin, lymph node and bone/soft tissue. There were six patients as myeloid sarcoma with preexisting or concurrent acute myeloid leukemia, one patient as de novo and one patient as acute myeloid leukemia with myelodysplasia related changes. One of the concurrent acute myeloid leukemia patients was Down syndrome related acute myeloid leukemia with myeloid sarcoma. Immunohistochemically, out of 8 patients, 4 were of myelomonocytic, 2 were of the myelocytic and 2 were of the monocytic differentiation. Conclusion: Myeloid sarcoma is a tumor mass made up of immature myeloid blasts appearing at an anatomical site other than bone marrow. Taking into account of having a challenging diagnosis, unusual cellular infiltration at any site on a patient especially with a history of acute myeloid leukemia should have myeloid sarcoma in their differential diagnosis. Keywords: Myeloid sarcoma, acute myeloid leukemia, myeloid neoplasia

Keywords:

Myeloid sarcoma, acute myeloid leukemia, myeloid neoplasia,

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