Induction of abnormal sperm heads in small mammals under chronic ionizing radiation
Induction of abnormal sperm heads in small mammals under chronic ionizing radiation
The results of this study show a mutagenic effect of low-dose ionizing radiation in male germ cells. The damage of male germcells was assessed by the frequency of abnormal sperm heads in tundra voles (Microtus oeconomus Pall.), bank voles (Myodes glareolusSchreb.), and field mice (Apodemus agrarius Pall.) from the 30 km exclusion zone around the Chernobyl nuclear power station andfor laboratory animals (mice and rats) under chronic γ-irradiation. The abnormal sperm head detection method used appeared to besensitive to conditions of low-dose irradiation and can consequently be recommended as a bioindicator to monitor environmental radiation pollution.
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- Burruel VR, Yanagimachi R, Whitten WK (1996). Normal mice
develop from oocytes injected with spermatozoa with grossly
misshapen heads. Biology of Reproduction 55: 709-714.
- Chemes HE, Rawe VY (2003). Sperm pathology: a step beyond
descriptive morphology. Origin, characterization and fertility
potential of abnormal sperm phenotypes in infertile men.
Human Reproduction Update 9 (5): 405-428.
- Daev EV, Dukelskaya AV (2004). Reproductive characteristics of
mouse males are influenced by the mouse female pheromone
2.5-dimethylpyrazine in the C57BL/6 strain. Ecological
Genetics 2 (1): 44-49 (in Russian with an abstract in English).
- Enciso M, Cisale H, Johnston SD, Sarasa J, Fernández JL et al. (2011).
Major morphological sperm abnormalities in the bull are
related to sperm DNA damage. Theriogenology 76 (1): 23-32.
doi: 10.1016/j.theriogenology.2010.12.034
- Evdokimov VV, Erasova VI, Orlova ЕV, Demin АI, Kodentsova VM
(2006). Monitoring the state of the reproductive system in the
liquidators of the Chernobyl accident. Almanac of Clinical
Medicine 10: 39-45 (in Russian).
- Gileva EA, Lyubashevskii NM, Starichenko VI, Chibiryak MV,
Romanov GN (1996). Hereditary chromosome instability
in common vole (Microtus Arvalis) from the region of the
Kyshtym nuclear meltdown: Fact or hypothesis? Russian
Journal of Genetics 32 (1): 99-104.
- Ieradi LA, Zima J, Allegra F, Kotlánová E, Campanella et al. (2003).
Evaluation of genotoxic damage in wild rodents from a polluted
area in the Czech Republic. Folia Zoologica 52 (1): 57-66.
- Kiseleva Y, Azova MM, Kodyleva TA, Kirillova AO, Ekimov
AN et al. (2017). The increase in aneuploidy of embryos
is associated with pathological morphology of the sperm.
Russian Journal of Genetics 53 (12): 1378-1381. doi: 10.7868/
S0016675817120050
- Kleshev MA, Osadchuk LV (2012). Modification of the testicular
function in laboratory male mice during social interactions:
effect of female presence. Bulletin of Experimental Biology
and Medicine 153 (2): 240-243. doi: 10.1007/s10517-012-
1686-8
- Kruczek M, Styrna J, Kapusta J (2013). Reproductive capacity of male
bank voles (Myodes glareolus Schreber, 1780) age-dependent
changes in functional activity of epididymal sperm. Belgian
Journal of Zoology 143 (2): 131-141.
- Kumar D, Salian SR, Kalthur G, Uppangala S, Kumari S et al.
(2013). Semen abnormalities, sperm DNA damage and global
hypermethylation in health workers occupationally exposed to
ionizing radiation. Plos One 8 (7): 1-8. doi: 10.1371/journal.
pone.0069927
- Osadchuk LV, Kleshev MA, Osadchuk AV, Tupikin AE, Morozov
IV et al. (2012). Phenotypic variation of spermatogenesis and
a search for associations with genetic polymorphism in 13
inbred mouse strains. Russian Journal of Genetics 48 (8): 823-
830. doi: 10.1134/S1022795412070101
- Ryabokon NI (2010). Multigenerational effects of chronic ionizing
radiation in natural populations of model mouse-like rodents
living in accidently radiocontaminated areas. NATO Science
for Peace and Security Series. Human and Societal Dynamics.
IOS Press. 73: 277-289. doi 10.3233/978-1-60750-645-4-277
- Saacke RG (2008). Sperm morphology: Its relevance to compensable
and uncompensable traits in semen. Theriogenology 70 (3):
473-478. doi:10.1016/j.theriogenology.2008.04.012
- Soares ER, Sheridan W, Segall M (1979). Increased frequencies of
aberrant sperm as indicators of mutagenic damage in mice.
Mutation Research 64 (1): 27-35.
- Taskaev AI, Bashlykova LA, Zainullin VG (2010). Ecological and
genetic monitoring of muridae from populations undergone
to the chronic irradiation. Radiation Biology Radioecology 50
(5): 560-571 (in Russian with an abstract in English).
- Wagner H, Cheng JW, Ko EY (2018). Role of reactive oxygen species
in male infertility: An updated review of literature. Arab
Journal of Urology 16: 35-43. doi.org/10.1016/j.aju.2017.11.001
- World Health Organization (2010). WHO Laboratory Manual for
the Examination and Processing of Human Semen. 5th ed.
Geneva. p. 272.
- Zakhidov ST, Gordeeva OF, Marshak TL (2001). A biological model
of accelerated senescence. 1. The rate of the spontaneous
mutation process in spermatogenesis of senescence-accelerated
mice. Biology Bulletin of the Russian Academy of Sciences 28
(1): 18-24.
- Zhou DD, Hao JL, Guo KM, Lu CW, Liu XD (2016). Sperm quality
and DNA damage in men from Jilin Province, China, who
are occupationally exposed to ionizing radiation. Genetics
and Molecular Research 15 (1). doi http://dx.doi.org/10.4238/
gmr.15018078