Tilmikosin ve sefkuinomun tek başına ve birlikte kullanımının bazı kanatlı patojenlerine karşı in vitro aktivitesi

İn vitro antibacterial activities of tilmicosin and cefquinomme alone or in combination againt certain poultry pathogens

The antimicrobial activities of cefquinome and tilmicosin were determined in vitro against P. multocida and O. rhinotracheale of poultry origin by serial broth macrodilution. Both antibiotics exhibited good in vitro antibacterial activity against the strains tested. The minimum inhibitory concentration (MIC) for cefquinome was 1.562 µg/ml and for tilmicosin was 0.78 µg/ml for both microorganisms. To investigate the effects of a combination of cefquinome and tilmicosin, the fractional inhibitory concentration (FIC) index was determined by checkerboard assay. The antimicrobial combination was additive against P. multocida (FIC=1) and indifferent against O. rhinotracheale (FIC=2).

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