Muhammed YAR, Mahmood AHMAD, Nadeem Irfan BUKHARI, Muhammad Naveed Akhtar KHAWAJA

Pharmacokinetics of oxytetracyline in sheep after various intravenous doses

Oksitetrasiklin'in farmakokinetigi 20 koyun üzerinde araştırıldı. Araştırmada koyunlara, 40, 80 ve 160 mg/kg'lık oksitetrasiklin, damardan enjekte edildi. Her örnek alımda, artan dozlarla birlikte, hayvanların hepsinde oksitetrasiklin konsantrasyonunun yükseldiği gözlendi. 40, 80 ve 160 mg/kg'lik damariçi ulaç uygulamasından sonra, oksitetrasiklinin plazma konsantrasyonlarındaki en yüksek değerleri sırasıyla 18.67 ± 0.09, 40.63 + 0.16 ve 86.51 ± 0.10 µg/ml oldu. Bu plazma konsantrasiyonları sırasıyla 10.88 ± 0.29, 5.87 ± 0.08 ve 7.35 ± 0.08 saatlik yarılanma süreleriyle azalmıştır. MRT değerlerine göre oksitetrasiklin 40, 80 ve 160 mg/kg'lık dozlardan sonra 11.23 ± 0.25, 5.78 ± 0.08 ve 6.73 ± 0.05 saat koyunlarda kalmıştır. Ilacın verilmesinden sonra Clt'nin 8.71 ± 0.08, 9.73 ± 0.06 ve 9.74 ± 0.03 ml/saat olduğu bulunmuştur. Bu çalışmada üç üstel dozdan sora Vd'nin 8.19 ± 0.2, 5.09 ± 0.16 ve 6.22 + 0.06 litre olduğu sonucuna varıldı. Böylece oksitetrasiklinin plazma konsantrasyonunun doza bağlı olduğu sonucuna varıldı.

Koyunlarda çeşitli damariçi dozlarından sonra aksitetrasiklin' in pharmakokinetiği

Pharmacokinetics of oxytetracycline were investigated in 20 sheep following intravenous injection of 40, 80 and 160 mg/kg doses. An increase in concentration of oxytetracycline was found with increasing dose at all the sampling times in each animal. The peak plasma concentration of oxytetracycline attained after intravenous administration of 40, 80 and 160 mg/kg of the drug was 18.67±0.09, 40.63±0.16 and 86.51±0.10 mg/ml, respectively. These plasma concentrations decreased with plasma half lives of 10.88 ± 0.29, 5.87 ± 0.08 and 7.35 ± 0.08 hours respectively. Oxytetracycyine resided, as indicated by MRT for 11.23±0.25, 5.78±0.08, 6.73±0.05 hours post dosing of 40, 80 and 160 mg/kg body weight of drug. After administration of the drug the Clt was observed to be 8.71±0.08, 9.73±0.06 and 9.74±0.03 ml/h. The Vd in the present study was concluded to be 8.19±0.2, 5.09±0.16 and 6.22±0.06 liters after three exponential doses. It was, therefore, concluded that the plasma concentration of oxytetracycline is dose relate d according to the present investigation

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