Seval YILMAZ

6690

Lipid Peroxidation, Antioxidant Enzymes and Pyruvate Kinase Activity in Rats With Carbon Tetrachloride-Induced Cirrhosis

Changes in the level of malondialdehyde (MDA, a degradative product of lipid peroxidation) and in the antioxidant defense system in rats with carbon tetrachloride-induced liver cirrhosis were studied, in order to determine whether there is any relation between these parameters and the disease. Liver cirrhosis was induced in Wistar-Albino rats by carbon tetrachloride (0.15 gr/100 gr body weight) which was injected subcutanously three times a week for six weeks. In the liver, the level of tissue malondialdehyde was analysed according to Yagi's method; and glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase activities according to Beutler's method. The level of liver malondialdehyde in the group with cirrhosis was significantly higher than in the control group (p

Anahtar Kelimeler:

Cirrhosis, lipid peroxidation, glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase.

Lipid Peroxidation, Antioxidant Enzymes and Pyruvate Kinase Activity in Rats With Carbon Tetrachloride-Induced Cirrhosis

Changes in the level of malondialdehyde (MDA, a degradative product of lipid peroxidation) and in the antioxidant defense system in rats with carbon tetrachloride-induced liver cirrhosis were studied, in order to determine whether there is any relation between these parameters and the disease. Liver cirrhosis was induced in Wistar-Albino rats by carbon tetrachloride (0.15 gr/100 gr body weight) which was injected subcutanously three times a week for six weeks. In the liver, the level of tissue malondialdehyde was analysed according to Yagi's method; and glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase activities according to Beutler's method. The level of liver malondialdehyde in the group with cirrhosis was significantly higher than in the control group (p

Keywords:

Cirrhosis, lipid peroxidation, glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase.,

Turkish Journal of Veterinary and Animal Sciences-Cover

ISSN: 1300-0128
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

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