Factors affecting colostrum quality of ewes and immunostimulation

Maternal antibodies play a major role in the development of the immune system of a young animal. Ideally, the transmission of maternal immunity to the foetus occurs in the uterus. However, in ruminants, as there is no maternal antibody transfer from the mother to her young by way of the uterus, the antibodies present in the colostrum are a vital necessity for newborn ruminants. After birth, an unhealthy neonatal period for the young animal and an unhealthy puerperal period for the mother can cause significant financial losses. In animal husbandry, due to the budget allocated for the treatment of diseases and the economic damage of breeding that can be caused by lasting problems created by disease, the importance given to preventive medicine has increased further. Therefore, in breeding, increasing the resistance against the disease agent is preferred instead of treating disease. This situation has resulted in more studies to improve the level of maternal and colostral antibodies as well as the widespread use of specific and nonspecific immunostimulants in veterinary medicine. In this review, the factors affecting the quality of ewe colostrum are discussed and the importance of colostrum quality for a newborn lamb is described. In addition, the methods used today to increase the quality of colostrum are presented.

Anahtar Kelimeler:

Key words: Ewe, newborn lamb, colostrum, immunostimulation

Factors affecting colostrum quality of ewes and immunostimulation

Keywords:

Key words: Ewe, newborn lamb, colostrum, immunostimulation,

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Pattinson, S.E., Davies, D.A.R., Winter, A.C.: Changes in the secretion rate and production of colostrum by ewes over the first 24 h post partum. Anim. Sci., 1995; 61: 63–68.
Campana W.M., Baumrucker C.R.: Hormones and growth factors in bovine milk. In: Jensen, R.G., Ed. Handbook of Milk Composition. Academic Press, San Diego. 1995; 467–494.
Rauprich, A.B.E., Hammon, H.M., Blum, J.W.: Influence of feeding different amounts of first colostrum on metabolic, endocrine and health status and on growth performance in neonatal calves. J. Anim. Sci., 2000; 78: 896–908.
Selk, G.E.: Management factors that affect the development of passive immunity in the newborn calf. In: Beef Cattle Handbook-2240. Extension Beef Cattle Resource Committee. 1998; 1–7.
Treacher, T.T.: Artificial rearing of lambs: A review. Vet. Rec., 1973; 92: 311–315.
Arda, M.: Meme dokusunun ve sekresyonlarının immunolojik fonksiyonları. In: Arda, M., Minbay, A., Aydın, N., Akay, Ö., İzgür, M., Diker, K.S. Eds. İmmunoloji. Medisan, Ankara. 1994; 107–112 (in Turkish).
Esser, D., Schmit, F.W., Peters, K.J., Von Korn, S.: Immunoglobulin G status of ewes and their lambs. J. Anim. Breed. Gen., 1989; 106: 120–124.
Brambell, F.W.R.: The passive immunity of the young mammal. Biol. Rev., 1958; 33: 488–530.
Campbell, S.G., Siegel, M.J., Knowlton, B.J.: Sheep immunoglobulins and their transmission to the neonatal lamb. New Zeal. Vet. J., 1977; 25: 361–365.
Neto, R.M., Packer, I.U., Prado, G.C.B., Bessi, R., Pauletti, P.: Colostral immunoglobulins absorption in Canchim and Nelore calves. Rev. Brasil. Zootec., 2004; 33: 1544–1547.
Tizard, I.: Immunity in the fetus and newborn. In: Tizard, I. Ed. Veterinary Immunology. 4th edn., W. B. Saunders Company, London. 1992; 248–257.
Zarrilli, A., Micera, A., Lacarpia, N., Lombardi, P., Pero, M.E., Pelegalli, A., d’Angelo, D., Mattia, M., Avallone, L.: Evaluation of ewe colostrum quality by estimation of enzyme activity levels. Rev. De Med. Vet., 2003; 154: 521–523.
Matte, J.J., Girard, C.L., Seosane, J.R., Brisson, G.J.: Absorption of colostral immunoglobulin G in the newborn dairy calf. J. Dairy Sci., 1982; 65: 1765–1770.
Stott, G.H., Marx, D.B., Menefee, B.E., Nightengale, G.T.: Colostral immunoglobulin transfer in calves. I. Period of absorption. J. Dairy Sci., 1979; 62: 1632–1638.
Lecce, J.G., Morgan, D.O.: Effect of dietary regimen on cessation of intestinal absorption of large molecules (closure) in neonatal pigs and lambs. J. Nutr., 1962; 78: 265–269.
Logan, E.F.: Factors influencing the quantity and quality of colostrum in the cow. Vet. Res. Comm., 1978; 2: 39–46.
Kirk, J.H.: Colostrum: The key to control of calfhood diseases and death loss. Veterinary Medicine Extension, University of California, Davis. 2003. Available at http://www.vetmed. ucdavis.edu/vetext/INF-DA/INF-DA_COLOSTRUM.HTML, accessed 28 November 2012.
Thomas, H.S.: Calves need colostrum to build immunities. Cattle Today. 2003. Available at http://www.cattletoday.com/ archive/2002/March/CT195.shtml, accessed 28 November 20
Logan, E.F.: The influence of husbandry on colostrum yield and immunoglobulin concentration in beef cows. Br. Vet. J., 1977; 133: 120–125.
Selk, G.E.: Disease protection of baby calves. Division of Agricultural Sciences and Natural Resources, Oklahoma State University. 2003. Available at http://osuextra.okstate.edu/pdfs/F3358web.pdf, accessed 28 November 2012.
Shubber, A.H., Doxey, D.L.: Immunoglobulin content of ewe colostrum: comparison between the right and left sides of the udder. Vet. Sci. Comm., 1978; 2: 141–144.
Al-Sabbagh, T.A.: Effect of nutritional status, age, breed, litter size and litter sex on colostral IgG levels for ewes delivered in Kuwait. Electronic J. Env. Agric. Food Chem., 2008; 7: 3199–3205.
Gallo, C., Davies, D.A.R.: Relationship of litter size and colostrum characters in Cambridge and Suffolk × Cambridge ewes. Arch. Med. Vet., 1987; 19: 47.
Roth, J.A., Kaeberle, M.L.: In vivo effect of ascorbic acid on neutrophil function in healthy and dexamethasone-treated cattle. Am. J. Vet. Res., 1985; 46: 2434–2435.
Ciupercescu, D.D.: Dynamics of serum immunoglobulin concentrations in sheep during pregnancy and lactation. Res. Vet. Sci., 1977; 22: 23–27.
Kaymaz, A.A., Bakırel, U., Çağtay, P., Tan, H.: The effects of serum IgG and trace elements-copper and zinc on the development of Kivircik lambs following colostrum intake. J. Fac. Vet. Med. Univ. Ist., 2000; 26: 475–481 (in Turkish with an abstract in English).
Logan, E.F.: Neonatal immunity with particular reference to colostrum. Cattle Pract., 1996; 4: 273–284.
Şentürk, S., Polat, Ü., Kennerman, E.: Kuru dönemde Levamizol uygulanan ineklerden doğan buzağıların immun düzeylerinin belirlenmesi. J. Fac. Vet. Med. Univ. Uludag, 2003; 22: 7–11 (in Turkish with an abstract in English).
Aydın, N.: İmmunostimülasyon ve immunostimülantlar. In: Arda, M., Minbay, A., Aydın, N., Akay, Ö., İzgür, M., Diker, K.S. Eds. İmmunoloji. Medisan, Ankara, 1994; 291–294 (in Turkish).
Shalaby, M.A., Saleh, S.M., El-Atrash, S., Sami, A.M., El-Sanousi, A.A., Saber, M.A., Reda, M.I.: Application of Corynebacterium cutis lysate as an immune stimulant in cattle. Mol. Biother., 1992; 4: 147–150.
Flesh, J., Harel, W., Nelken, D.C.: Immunopotentiating effect of levamisole in the prevention of bovine mastitis, fetal death and endometritis. Vet. Rec., 1982; 111: 56–57.
Al-Izzi, S.A., Maxie, M., Savan, M.: The pulmonary clearance of Pasteurella haemolytica in calves given Corynebacterium parvum and infected with parainfluenza-3 virus. Can. J. Comp. Med., 1982; 46: 85–90.
Gialdroni, G.G.: Bacterial products as immunostimulating agents. Int. Arc. Allergy Immun., 1982; 76: 119–127.
Chapes, S.K., Haskill, S.: Evidence for granulocyte-mediated macrophage activation after C. parvum immunization. Cell Immun., 1983; 75: 367–377.
Büttner, M., Strube, W., Wolf, G., Hoerstke, M.: Parapoxvirus als induktor unspezifischer abwehrmechanismen. Tierärzliche Umschau, 1987; 42: 14–21 (in German with an abstract in English).
Marsig, E., Stickl, H.: Investigation on the efficacy of immunomodulators and animal pox virus preparations against tumor cell lines in vitro. J. Vet. Med. Series B, 1988; 35: 601– 60
Mayr, A., Büttner, M.: Neue erkenntnisse über die Grundlagen der Paramunität und Paramunisierung. Berliner und Münchener Tierärzliche Wochenscrift, 1984; 97: 429–435 (in German with an abstract in English).
Mayr, A., Büttner, M., Wolf, G., Meyer, H., Czerny, C.: Experimenteller Nachweis paraspezifisher Wirkungen von gereinigten und inaktivierten Pockenviren. J. Vet. Med. Series B, 1989; 36: 81–99 (in German with an abstract in English).
Brunner, C.J., Muscoplat, C.C.: Immunomodulatory effect of levamisole. J. Am. Vet. Med. Assoc., 1980; 176: 1159–1161.
Gürbulak, K., Kılıçarslan, M.R.: The effect of Levamisole administration on the postpartum mastitis, metritis and foetal death in the pregnant cows. J. Vet. Fac. Med. Ist. Univ., 2004; 30: 35–46 (in Turkish with an abstract in English).
Ağalar, C.: Microorganism and immunostimulation. J ANKEM, 2008; 22 (Suppl. 2): 180–184.
Suzuki, M., Kikuchi, T., Takatsuki, F., Hamuro, J.: Curative effects of combination therapy with lentinan and interleukin-2 against established murine tumors, and the role of CD8positive T cells. Cancer Immun. Immunother., 1994; 38: 1–8.
Aydın, K., Usluer, G.: Broncho-Vaxom (OM-85 BV). İnfeks. Hast. Klinik Mikrobiyol. Derg., 2006; 11 (Suppl. 1): 11–15 (in Turkish with an abstract in English).
Blecha, F.: Immunomodulation: A means of disease prevention in stressed livestock. J. Anim. Sci., 1988; 66: 2084–2090.
Linker-Israeli, M., Bakke, A.C., Kitridou, R.C., Gendler, S., Gillis, S., Horwitz, D.A.: Defective production of interleukin 2 and interleukin 1 in patients with systemic lupus erythematosus (SLE). J. Immunol., 1983; 130: 2651–2655.
Thoman, M.L., Weigle, W.O.: Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis. J. Immunol., 1982; 128: 2358–2360.
Yılmaz, H., Gün, H.: Biological and immunological importance of Vitamin E and selenium. Bültendif, 1995; 5: 2–4 (in Turkish with an abstract in English).
Turna Yılmaz, Ö., Kaşıkçı, G., Gündüz, M.C.: Benefits of pregnant sheep immunostimulation with Corynebacterium cutis on post-partum and early newborn’s life IgG levels, stillbirth rate and lamb’s weight. Sm. Rum. Res., 2011; 97: 146–151.