Nora Marıa CARCAMO ARECHIGA, Gabriela SILVA HIDALGO, Silvia del Carmen COTA-GUAJARDO, Martin LOPEZ VALENZUELA, Margarita del Socorro DAVILA PAREDES

Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog

A male mixed breed street dog (age unknown) presented with an ocular mass and multiple ulcerated subcutaneous noduleson both hind limbs which bled easily when touched. Inspection of the genital organs revealed that no masses were present. The ocularmass and nodules were diagnosed as a transmissible venereal tumor (TVT) by fine-needle aspiration cytology. The total remissionof the tumor was achieved after 5 applications of vincristine sulfate. The dog was adopted during the remission period, but 5 monthsafter adoption he developed neurological signs and died. The necropsy revealed a mass located in the trunk of the corpus callosum ofthe right hemisphere of the brain. The cytological, histological, and PCR findings of the brain mass were consistent with a TVT. Thesefindings highlight the need to consider the aggressive metastatic potential of canine TVT, even after apparently effective chemotherapy

PDF

___

1. Strakova A, Murchison EP. The changing global distribution and prevalence of canine transmissible venereal tumor. BMC Veterinary Research 2014; 10 (168): 1-10. doi: 10.1186/s12917- 014-0168-9
2. Mendoza VN, Chavera CA, Falcón PN, Perales CR. Frequency of the transmissible venereal tumor in dogs: caseload in the pathology laboratory of the National University of San Marcos (Period 1998-2004). Revista de Investigaciones Veterinarias del Perú 2010; 21 (1): 42-47 (in Spanish with an abstract in English).
3. Grandez RR, de Priego CM, Yi AP, Torres PL. Extragenital transmissible venereal tumor: retrospective study of 11 cases. Revista de Investigaciones Veterinarias del Perú 2011; 22 (4): 342-350 (in Spanish with an abstract in English).
4. Pineda CJ, Romero NC, Mendoza MGD, García CCA, Plata F et al. Canine transmissible venereal tumor in the metropolitan area of Mexico city. Revista Científica FCV-LUZ 2010; 20 (4): 362-366 (in Spanish with an abstract in English).
5. Couto do Amaral AV, de Oliveira FR, da Silva MAP, Leao BM, da Costa L et al. Intraocular transmisible venereal tumor in a dog case report. Veterinaria e Zootecnia 2012; 19 (1): 79-85 (in Portuguese with an abstract in English).
6. Rezaei MS, Azizi S, Shahheidaripour S, Rostami S. Primary oral and nasal transmissible venereal tumor in a mix-breed dog. Asian Pacific Journal of Tropical Biomedicine 2016; 6 (5): 443-445. doi: 10.1016/j.apjtb.2016.03.006
7. Barbalho LT, Tertuliano MPV, Lira RN, Jark PC, Passino MJF et al. Canine transmissible venereal tumor in a dog with single extragenital location. Veterinaria e Zootecnia 2013; 20 (1): 57- 61 (in Portuguese with an abstract in English).
8. Pinczowski P, Gimeno M, Aceña C, Villegas A, de Martino A et al. Brain metastasis in a case of canine transmissible venereal tumor after a supposed successful treatment with vincristine sulfate. Acta Veterinaria-Beograd 2015; 65 (1): 137-142. doi: 10.1515/acve-2015-0011
9. Ferreira AJA, Jaggy A, Varejao AP, Ferreira MLP, Correia JMJ et al. Brain and ocular metastases from a transmissible venereal tumour in a dog. Journal of Small Animal Practice 2000; 41 (4): 165-168. doi: 10.1111/j.1748-5827.2000.tb03187.x
10. Chikweto A, Kumtheka S, Larkin H, Deallie C, Tiwari KP et al. Genital and extragenital canine transmissible venereal tumor in dogs in Granada, West Indies. Open Journal of Veterinary Medicine 2013; 3 (2): 111-114. doi: 10.4236/ojvm.2013.32018
11. Chandrasekar M, Pothiappan P, Balachandran C. Therapeutic management of cutaneous transmissible venereal tumors without genital involvement in a dog. Intas Polivet 2013; 14 (2): 481-482.
12. Setthawongsin C, Techangamsuwan S, Tangkawattana S, Rungsipipat A. Cell-based polymerase chain reaction for canine transmissible venereal tumor (CTVT) diagnosis. Journal of Veterinary Medical Science 2016; 78 (7): 1167-1173. doi: 10.1292/jvms.15-0710
13. Purohit G. Canine transmissible venereal tumor: a review. Internet Journal of Veterinary Medicine 2009; 6 (1): 1-7.
14. Pai CC, Kuo TF, Mao SJ, Chuang TF, Lin CS et al. Immunopathogenic behaviors of canine transmissible venereal tumor in dogs following an immunotherapy using dendritic/tumor cell hybrid. Veterinary Immunology and Immunopathology 2011; 139 (2-4): 187-199. doi: 10.1016/j. vetimm.2010.10.013