Elma OMERAGIC, Jasmina DJEDJIBEGOVIC, Amila TURALIC, Faruk CAKLOVICA, Aleksandra MARJANOVIC, Miroslav SOBER, Haris NIKSIC, Amir CAUSEVIC

Arsenic, cadmium, mercury, and lead in date mussels from the Sarajevo fish market (Bosnia and Herzegovina): a preliminary study on the health risks

The main objective of this study was to determine the content of heavy metals (Cd, Pb, Hg) and metalloid (As) in samplesof date mussels (Lithophaga lithophaga L., 1758) in order to evaluate the health risks for mussel consumers. Samples of shellfish wereobtained from commercial sources and fishery in the area of Sarajevo. The content of heavy metals and arsenic is determined in a totalof 46 samples. Samples were prepared by microwave digestion. For the analysis of total As, cadmium and lead, an atomic absorptionspectrophotometer with graphite furnace was used, while mercury content was determined using a direct Hg analyser. In all samples,the content of heavy metals and arsenic was above the quantification limit of the given methods. The content of all analysed metals andmetalloid was below the limits of their maximum allowable concentration in food, according to the current regulations in Bosnia andHerzegovina and the European Union. Evaluation of the public health risks associated with date mussels’ consumption indicates thatthere is no evident risk for a moderate adult consumer.

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1. Antonijevic B, Jankovic S, Curcic M, Durgo K, Stokic E et al. Risk characterization for mercury, dichlorodiphenyltrichloroethane and polychlorinated biphenyls associated with fish consumption in Serbia. Food and Chemical Toxicology 2011; 49 (10): 2586-2593. doi: 10.1016/j.fct.2011.06.078
2. Storelli MM. Potential human health risks from metals (Hg, Cd, and Pb) and polychlorinated biphenyls (PCBs) via seafood consumption: Estimation of target hazard quotients (THQs) and toxic equivalents (TEQs). Food and Chemical Toxicology 2008; 46: 2782-2788. doi: 10.1016/j.fct.2008.05.011
3. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Safety evaluation of certain food additives and contaminants. WHO Food Additives 2007; 58: 269-317.
4. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Safety evaluation of certain food additives and contaminants. WHO Food Additives 2011; 63: 605-685.
5. EFSA Scientific Committee. Scientific panels and units in the absence of actual measured data. EFSA Journal 2012; 10: 2579. doi: 10.2903/j.efsa.2012.2579
6. Ured za Zakonodavstvo. Pravilnik o izmjenama pravilnika o najvećim dozvoljenim količinama određenih kontaminanata u hrani. Službeni glasnik BiH 2018; 84: 15-18 (in Bosnian).
7. The Commission of the European Communities. Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official Journal 2016; L 364/5: 1-39.
8. Food and Agriculture Organization. Food Supply-Livestock and Fish Primary Equivalent. Rome, Italy: FAO;2018.
9. Djedjibegovic J, Marjanovic A, Burnic S, Omeragic E, Dobraca A et al. Polychlorinated biphenyls (PCBs) in fish from the Sana River (Bosnia and Herzegovina): a preliminary study on the health risk in sportfishermen. Journal of Environmental Science and Health, Part B 2015; 50: 638-644.
10. World Health Organization. GEMS/Food Consumption Database. Geneva, Switzerland: WHO; 2012.
11. European Food Safety Authority. Dietary exposure to inorganic arsenic in the European population. EFSA Journal 2014; 12 (3): 3597. doi: 10.2903/j.efsa.2014.3597
12. European Food Safety Authority. Statement on the applicability of the Margin of Exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed. EFSA Journal 2012; 10 (3): 2578. doi: 10.2903/j.efsa.2012.2578
13. Markovic J, Joksimovic D, Stankovic S. Trace element concentrations in wild mussels from the coastal area of the southeastern Adriatic, Montenegro. Archives of Biological Science Belgrade 2012; 64: 265-275. doi: 10.2298/ ABS1201265M
14. Bogdanovic T, Ujevic I, Sedak M, Listeš E, Simat V et al. As, Cd, Hg and Pb in four edible shellfish species from breeding and harvesting areas along the eastern Adriatic Coast, Croatia, Analytical Methods 2014; 146: 197-203. doi: 10.1016/j. foodchem.2013.09.045
15. Sharif, Chong E, Meng KC. Human Health Risk Assessment of Heavy Metals in Shellfish from Kudat, Sabah. Malaysian Journal of Nutrition 2016; 22 (2): 301-305.
16. Olmedo P, Pla A, Hernández AF, Barbier F, Ayouni L et al. Determination of toxic elements (mercury, cadmium, lead, tin and arsenic) in fish and shellfish samples. Risk assessment for the consumers. Environment International 2013; 59: 63-72. doi: 10.1016/j.envint.2013.05.005
17. Gavrilovic M, Srebocan E, Petrinec Z, Pompe-Gotal J, Prevendar-Crnic A. Teški metali u kamenicama i dagnjama molostonskog zaljeva. Naše More 2004; 51: 50-58 (in Croatian).
18. European Food Safety Authority. Scientific opinion on arsenic in food. EFSA Journal 2009; 7: 1351. doi: 10.2903/j. efsa.2009.1351
19. European Food Safety Authority. Cadmium dietary exposure in the European population. EFSA Journal 2012; 10: 2551. doi: 10.2903/j.efsa.2012.2551
20. European Food Safety Authority. Lead dietary exposure in the European population. EFSA Journal 2012; 10: 2831. doi: 10.2903/j.efsa.2012.2831
21. European Food Safety Authority. Scientific opinion on lead in food. EFSA Journal 2010; 8: 1570. doi: 10.2903/j.efsa.2010.1570
22. Sirot V, Guérin T, Volatier JL, Leblanc JC. Dietary exposure and biomarkers of arsenic in consumers of fish and shellfish from France. Science of the Total Environment 2009; 407: 1875- 1885. doi: 10.1016/j.scitotenv.2008.11.050
23. Ferreccio C, Gonzalez C, Milosavjlevic V, Marshall G, Sancha AM et al. Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiolog 2000; 11: 673-679. doi: 10.1097/00001648-200011000-00010
24. Leblanc JC. CALIPSO Study: Fish and Seafood Consumption Study and Biomarker of Exposure to Trace Elements, Pollutants and Omega 3. Paris, France: AFSSA; 2006.
25. Francesconi KA. Arsenic species in seafood: origin and human health implications. Pure Applied Chemistry 2010; 82: 373- 381. doi: 10.1351/PAC-CON-09-07-01
26. Xia Y, Wade TJ, Wu K, Li Y, Ning Z et al. Well water arsenic exposure, arsenic induced skin-lesions and self-reported morbidity in Inner Mongolia. International Journal of Environmental Research and Public Health 2009; 6: 1010- 1025. doi: 10.3390/ijerph6031010
27. Chiou HY, Chiou ST, Hsu YH, Chou YL, Tseng CH et al. Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8.102 residents in an arseniasis endemic area in northeastern Taiwan. American Journal of Epidemiology 2001; 153: 411-418. doi: 10.1093/aje/153.5.411