A retrospective study of tetralogy of Fallot in dogs

Tetralogy of Fallot is a rare congenital heart defect; however, it is the most common cyanotic heart malformation in humans and animals. It consists of a ventricular septal defect, pulmonic stenosis, displacement of the aortic root, and hypertrophy of the right ventricle. At the Department of Internal Medicine Clinic of Diseases of Horses, Dogs, and Cats at the Wroclaw University of Environmental and Life Sciences, patients with Fallot syndrome constituted 4.44% of all patients with congenital heart diseases. There was no breed predisposition found. The most common clinical signs were exercise intolerance, dyspnea, and cyanosis of the mucous membranes, but it can also be asymptomatic. Echocardiography is considered to be the best method for diagnosing this congenital heart disease. Contrast angiocardiography can be used to confirm the diagnosis or as a complement to diagnosis. Surgery is the only effective method of treatment; however, for animals, we only provide palliative treatment.

A retrospective study of tetralogy of Fallot in dogs

Tetralogy of Fallot is a rare congenital heart defect; however, it is the most common cyanotic heart malformation in humans and animals. It consists of a ventricular septal defect, pulmonic stenosis, displacement of the aortic root, and hypertrophy of the right ventricle. At the Department of Internal Medicine Clinic of Diseases of Horses, Dogs, and Cats at the Wroclaw University of Environmental and Life Sciences, patients with Fallot syndrome constituted 4.44% of all patients with congenital heart diseases. There was no breed predisposition found. The most common clinical signs were exercise intolerance, dyspnea, and cyanosis of the mucous membranes, but it can also be asymptomatic. Echocardiography is considered to be the best method for diagnosing this congenital heart disease. Contrast angiocardiography can be used to confirm the diagnosis or as a complement to diagnosis. Surgery is the only effective method of treatment; however, for animals, we only provide palliative treatment.

___

  • Neill, C.A., Clark, B.E.: Tetralogy of Fallot. The first 300 years. Texas Heart Inst. J., 1994; 21: 272–279.
  • Michaelson, M., Ho, S.Y.: Congenital Heart Malformations in Mammals: An Illustrated Text. Imperial College Press, London. 2000; 132–134.
  • Agren, E., Soderberg, A., Morner, T.: Fallot’s tetralogy in a European brown bear (Ursus arctos). J. Wildl. Dis., 2005; 41: 825–828.
  • Mizia-Stec, K., Gąsior, Z., Haberka, M., Oleś, R., Adamczyk, T.: Adult patient after correction of tetralogy of Fallot – diagnostic and therapeutic issues. Pol. Arch. Med. Wewn., 2007; 117: 38– 43 (article in Polish with abstract in English).
  • Neirotti, R., Galindez, E., Kreutzer, G., Coronel, A.R., Pedrini, M., Becau, L.: Tetralogy of Fallot with subpulmonary ventricular septal defect. Ann. Thorac. Surg., 1978; 25: 51–56.
  • Vargas, F.J., Kreutzer, G.O., Pedrini, M., Capelli, H., Coronel, A.: Tetralogy of Fallot with subarterial ventricular septal defect. J. Thorac. Cardiovasc. Surg., 1986; 92: 908–912.
  • Kirklin, J.W., Barratt-Boyes, B.G.: Cardiac Surgery. Churchill Livingstone, New York. 1993: 247–249.
  • Therrien, J., Webb, G.D. Congenital heart disease in adults. In: Braunwald, E., Zipes, D., Libby, P., Eds. Heart Disease: A Textbook of Cardiovascular Medicine. 6th edn., WB Saunders, Philadelphia. 2001: 1592–1621.
  • Apitz, C., Webb, G.D., Remington, A.N.: Tetralogy of Fallot. Lancet, 2009; 374: 1462–1471.
  • Ware, A.W.: Cardiovascular Disease in Small Animal Medicine. Manson Publishing, London. 2007.
  • Park, I.C., Lee, H.S., Kim, J.T., Lee, J.S., Lee, S.G., Hyun, C.: Pentalogy of Fallot in a Korean Sapsaree dog. J. Vet. Med. Sci., 2007; 69: 73–76.
  • Helbing, W.A., de Roos, A.: Clinical applications of cardiac magnetic resonance imaging after repair of tetralogy of Fallot. Pediatr. Cardiol., 2000; 21: 70–79.
  • Nadas, A.S.: Tetralogy of Fallot. In: Fyler, D.C., Ed. Nadas’ Pediatric Cardiology. Hanley & Belfus, Philadelphia. 1992: 471–491.
  • Oliveira, P., Domenech, O., Silva, J., Vannini, S., Bussadori, R., Bussadori, C.: Retrospective review of congenital heart disease in 976 dogs. J. Vet. Intern. Med., 2011; 25: 477–483.
  • Tidholm, A.: Retrospective study of congenital heart defects in 151 dogs. J. Small Anim. Pract., 1997; 38: 94–98.
  • Gregori, T., Gomez Ochoa, P., Quintavalla, F., Mavropoulou, A., Quintavalla, C.: Congenital heart defects in dogs: a double retrospective study on cases from University of Parma and University of Zaragoza. Ann. Fac. Medic. Vet. di Parma, 2008; 28: 79–90.
  • Patterson, D.F.: Epidemiologic and genetic studies of congenital heart disease in the dog. Circ. Res., 1968; 23: 171–202.
  • Eldadah, Z.A., Hamosh, A., Biery, N.J., Montgomery, R.A., Duke, M., Elkins, R., Dietz, H.C.: Familial tetralogy of Fallot caused by mutation in the jagged1 gene. Hum. Molec. Genet., 2001; 10: 163–169.
  • Goldmuntz, E., Geiger, E., Benson, D.W.: NKX2.5 mutations in patients with tetralogy of Fallot. Circulation, 2001; 104: 2565– 25
  • Pizutti, A., Sarkozy, A., Newton, A.L., Conti, E., Flex, E., Digilio, M.C., Amani, F., Gianni, D., Tandoi, C., Marino, B., Crossley, M., Dallapiccola, B.: Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. Hum. Mutat., 2003; 22: 372–377.
  • Patterson, D.F, Pyle, R.L., Van Mierop, L., Melbin, J., Olson, M.: Hereditary defects of the conotruncal septum in Keeshond dogs: pathologic and genetic studies. Am. J. Cardiol., 1974; 34: 187–205.
  • Werner, P., Raducha, M.G., Prociuk, U., Ostrander, E.A., Spielman, R.S., Kirkness, E.F., Patterson, D.F, Henthorn, P.S.: The keeshond defect in cardiac conotruncal development is oligogenic. Hum. Genet., 2005; 116: 368–377.
Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Isolation of Streptococcus species from the tonsils of slaughtered pigs

Arzu Funda BAĞCIGİL, Serkan İKİZ, Kemal METİNER, Naciye Yakut ÖZGÜR, Seyyal AK, Ahmet Atila ILGAZ

Patellar fracture and patellar tendon rupture in a dog

Murat SARIERLER, İbrahim AKIN, Ali BELGE, Nuh KILIÇ

Comparative imaging of the vesicular glands in New Zealand white rabbits (Oryctolagus cuniculus)

Rosen DIMITROV, Kamelia STAMATOVA, Dimitar KOSTOV

Animal skeletal remains of the Theodosius harbor: general overview

Vedat ONAR, Gülsün PAZVANT, Hasan ALPAK, Nazan GEZER İNCE, Altan ARMUTAK, Zeynep Sevim KIZILTAN

Effects of feeding dry fat and yeast culture on broiler chicken performance

Mutassim Mohamed ABDELRAHMAN

Susceptibility of Prototheca zopfii strains isolated from cows with mastitis to chlorhexidine and iodine

Henryk KRUKOWSKI, Andrzej LISOWSKI, Bozena NOWAKOWICZ-DEBEK, Lukasz WLAZLO

Whole-blood thrombelastography using calcium chloride activation in healthy cats

Ramazan ÇÖL, Alicia MONTGOMERY, Maria Cristina IAZBIK, Ashley DEFELICE, Paulo Vilar SAAVEDRA, Guillermo COUTO

Shepherd dogs as a common source for Salmonella enterica serovar Reading in Garmsar, Iran

Taghi ZAHRAEI SALEHI, Mahdi ASKARI BADOUEI, Omid MADADGAR, Seyed Reza GHIASI, Iradj ASHRAFI TAMAI

Effect of oocyte quality and activation protocols on bovine embryo development following intracytoplasmic sperm injection

Ömer KORKMAZ, Şükrü KÜPLÜLÜ, Yüksel AĞCA, İbrahim Mert POLAT

Changes in the bioactive protein concentrations in the bovine colostrum of Jersey and Polish Holstein–Friesian cows

Monika SOBCZUK-SZUL, Zofia WIELGOSZ-GROTH, Marek WRO&#;SKI, Arkadiusz RZEMIENIEWSKI