Muhsin Akbaba, Burak KURT, Ersin NAZLICAN

Yeni Coronavirus Salgını

Amaç: Bu çalışmanın amacı, halk sağlığını tehdit eden yeni bir coronavirus salgını hakkında bilgi sahibi olmaktır.Yöntem: Pubmed, Web of Science ve Google Scholar veri tabanlarında ve Google arama motorunda“MERS-CoV” ve “Coronavirus” anahtar kelimeleri aranarak bulunan ilgili makaleler çalışma kapsamına alınmıştır. Bulgular: MERS-CoV olarak adlandırılan bu virüs, Suudi Arabistan'dan çıkmış, pek çok ülkeye yayılmış ve beraberinde ölümler getirmiştir. Akut alt solunum yolları enfeksiyonu yapan virüs, esas olarak develerden insanlara bulaşmakta, ayrıca insandan insana da bulaşabilmektedir. Hac mevsimi nedeniyle, MERS hastası sayısının katlanabileceği düşünülmektedir. Sonuç: Şu an için tedavisi olmayan hastalığın engellenmesi için koruyucu sağlık önlemleri alınması çok önemlidir.

Anahtar Kelimeler:

MERS, Coronavirus, Salgın

A New Coronavirus Outbreak: MERS-CoV

Objective: The objective of this study is to gain knowledge about a new coronavirus epidemic that threatens public health. Method: “MERS-CoV” and “Coronavirus” keywords were searched in the Pubmed, Web of Science and Google Scholar databases and in the Google search engine; relevant articles were studied. Results: A new coronavirus is a threat to public health. The so-called MERS-CoV virus originated in Saudi Arabia, spread over many countries and has caused many deaths. It causes acute lower respiratory tract infections that are mainly transmitted to humans from camels, and also can be passed from person to person. Due to the upcoming Hajj season, the number of MERS patients is expected to rise. Conclusion: For the moment, the disease is incurable and it is very important to take preventive health measures to evade it.

Keywords:

MERS, coronavirus, outbreak,

PDF

___

Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med ;348:1953-1966.
Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute ,361:1319-1325. syndrome. Lancet
World Health Organization. Summary table of SARS cases by country, 1 November – 7 August 2003 [Online]. Available at: http://www.who.int/csr/sars/country/200
_08_15/en/index.html. Accessed May 22, Guan Y, Zheng BJ, He YQ, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 2003;302:276-278.
Lau SK, Woo PC, Li KS, et al. Severe acute respiratory syndrome virus in Chinese horseshoe bats. Proc Natl Acad Sci USA 2005;102:14040-14045.
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med ;367:1814-1820.
Bermingham A, Chand MA, Brown CS, et al Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill 2012; :20290 http://www.eurosurveillance.org/images/d ynamic/EE/V17N40/art20290.pdf. Accessed May 22, 2014. Available at:
Middle East respiratory syndrome coronavirus (MERS-CoV) – Saudi Arabia Online]. http://www.who.int/csr/don/07- november-2014-mers/en/. Accessed Nov , 2014. Available at:
European Centre for Disease Prevention and Control. Epidemiological update: Middle East respiratory syndrome coronavirus (MERS-CoV). Nov 05, 2014 [Online]. Available http://ecdc.europa.eu/en/press/news/_lay outs/forms/News_DispForm.aspx?List=8db c-fe2d-476c-9133- ff4cb1b568&ID=1102. Accessed Nov 30, at:
T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu. 12.05.2014 tarihli MERS bilgi notu Online]. http://www.thsm.gov.tr/upload/files/_llere %20MERS%20May_s%202014.pdf. Accessed Nov 30, 2014. at:
Middle East respiratory syndrome coronavirus (MERS-CoV) – Turkey. Oct 24, Online]. Available at: http://www.who.int/csr/don/24-october- mers/en/. Accessed Nov 30, 2014.
Raj VS, Mou H, Smits SL, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature ;495:251-254. Raj VS, Smits SL, Provacia LB, et al. Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4 mediated entry of the Middle East respiratory syndrome coronavirus. J Virol ;88(3):1834-1838.
Reusken CB, Haagmans BL, Muller MA, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis ;13(10):859-866. Perera R, Wang P, Gomaa M, et al. Seroepidemiology for MERS coronavirus using pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June2013. Euro
Surveill 2013;18:20574 [Online]. Available at: http://www.eurosurveillance.org/images/d ynamic/EE/V18N36/art20574.pdf. Accessed Nov 30, 2014. and Hemida MG, Perera RA, Wang P, et al.
Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013.
Euro Surveill 2013;18(50):20659 [Online]. Available http://www.eurosurveillance.org/images/d ynamic/EE/V18N50/art20659.pdf. Accessed Nov 30, 2014. at:
Reusken CB, Ababneh M, Raj VS, et al. Middle coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013. Euro Surveill Available http://www.eurosurveillance.org/images/d ynamic/EE/V18N50/art20662.pdf. Accessed Nov 30, 2014. Syndrome ;18(50):20662 Online]. at:
Memish ZA, Zumla AI, Al-Hakeem RF, Al- Rabeeah AA, Stephens GM. Family cluster of Middle coronavirus infections. N Engl J Med ;368:2487-2494. syndrome
Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle East respiratory estimation of pandemic risk. Lancet ;382:694-699. coronavirus: Centers for Disease Control and Prevention. syndrome (MERS): case definitions [Online]. Available http://www.cdc.gov/coronavirus/mers/cas e-def.html. Accessed Nov 30, 2014. at:
Health Regulations for travellers to the Kingdom of Arabia Saudi Arabia Perfoming for Pilgrimage (Hajj) & Umra - 1434H (2013) Online]. Available at: https://www.muis.gov.sg/cms/uploadedFil es/MuisGovSG/News_Events/Announceme nts/Health%20Regulations%20for%20Trav ellers%20Performing%20Umrah%20and%
Haj_MOH%20Saudi.pdf. Accessed Nov 30, Centers for Disease Control and Prevention. Hajj and Umrah, 2013 [Online]. Available http://www.cdc.gov/features/HajjAndUmr ah/. Accessed Nov 30, 2014. at:
MERS-CoV Hastalığı Sağlık Çalışanları Rehberi (Bilim Kurulu Çalışması) [Online]. Available http://thsk.saglik.gov.tr/Dosya/02/mers_re hberi.pdf. Accessed Nov 30, 2014. at:
MERS-CoV Olası Vaka Bilgi ve Laboratuvar Available http://thsk.saglik.gov.tr/Dosya/02/zoonoti k/mers_istem_formu.pdf. Accessed Nov 30, Formu Online]. at: Memish ZA, Zumla AI, Assiri A. Middle East respiratory syndrome coronavirus infections in health care workers. N Engl J Med Available http://www.nejm.org/doi/pdf/10.1056/NE JMc1308698. Accessed Nov 30, 2014. at:
Fukuda K. Emergence of novel coronavirus: global context. East Mediterr Health J 2013;19(Suppl. 1):S5e6 [Online]. Available http://applications.emro.who.int/emhj/v19 /Supp1/EMHJ_2013_19_Supp1_S5_S6.pdf. Accessed Nov 30, 2014. at:
Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle East respiratory estimationof ;382(9893):694-699. coronavirus: risk. Lancet
Khan K, Sears J, Hu VW et al. Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia. PLoS Curr ecurrents.outbreaks.a7b70897ac2fa4f79b5 ;5: Health Organization. Online]. Available at: