Betül ERSOY, Mine ÖZKOL, Seniha KİREMİTCİ, Ahmet ERGİN, Bayram ÖZHAN

Waist to height ratio: a simple screening tool for nonalcoholic fatty liver disease in obese children

Özhan B, Ersoy B, Özkol M, Kiremitci S, Ergin A. Waist to heightratio: a simple screening tool for nonalcoholic fatty liver disease in obesechildren. Turk J Pediatr 2016; 58: 518-523.Simple predictors are needed for the screening of nonalcoholic fatty liver disease(NAFLD) in obese children. We aimed to assess the role of anthropometricparameters in the prediction of NAFLD. Three hundred and thirty two obesechildren (152 male, 180 female) aged 4.6-17.0 years were included in thisstudy. Weight, height, waist (WC), and hip circumference were measured.Body mass index (BMI), waist-hip-ratio (WHR), and waist-height-ratio (WHtR)were calculated. Obesity was defined as BMI for age and sex >= 95th percentile.NAFLD was diagnosed using ultrasonography (US). NAFLD was present in60.8% of obese children. Fatty liver prevalence differed significantly by genderand puberty (55.0% of girls vs 67.7% of boys, and 28.7% in prepubertal vs71.3% in pubertal children; p

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1. Liu Q, Bengmark S, Qu S. The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease. Lipids Health Dis 2010; 9: 42.
2. Schwimmer JB, Pardee PE, Lavine JE, Blumkin AT, Cook S. Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 2008; 118: 277-283.
3. Bozic MA, Subbarao G, Molleston JP. Pediatric nonalcoholic fatty liver disease. Nutr Clin Pract 2013; 28: 448-458.
4. Molleston JP, White F, Teckman J, Fitzgerald JF. Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastroenterol 2002; 97: 2460-2462.
5. Brunt EM. Noalcoholic steatohepatitis. Semin Liver Dis 2004; 24: 3-20.
6. Conlon BA, Beasley JM, Aebersold K, Jhangiani SS, Wylie-Rosett J. Nutritional management of insulin resistance in nonalcoholic fatty liver disease (NAFLD). Nutrients 2013; 5: 4093-4114.
7. Morandi A, Maffeis C. Predictors of metabolic risk in childhood obesity. Horm Res Paediatr 2014; 82: 3-11.
8. Vajro P, Lenta S, Socha P, et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr 2012; 54: 700-713.
9. Clemente MG, Mandato C, Poeta M, Vajro P. Pediatric nonalcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions. World J Gastroenterol 2016; 22: 8078-8093.
10. Sartorio A, Del Col A, Agosti F, et al. Predictors of non-alcoholic fatty liver disease in obese children. Eur J Clin Nut 2007; 61: 877-883.
11. Elizondo-Montemayor L, Serrano-González M, UgaldeCasas PA, Bustamante-Careaga H, Cuello-García C. Waist-to-height: cutoff matters in predicting metabolic syndrome in Mexican children. Metab Syndr Relat Disord 2011; 9: 183-190.
12. Zhang HX, Xu XQ, Fu JF, Lai C, Chen XF. Predicting hepatic steatosis and liver fat content in obese children based on biochemical parameters and anthropometry. Pediatr Obes 2015; 10: 112-117.
13. Lin YC, Chang PF, Yeh SJ, Liu K, Chen HC. Risk factors for liver steatosis in obese children and adolescents. Pediatr Neonatol 2010; 51: 149-154.
14. Zhang X, Wan Y, Zhang S, et al. Nonalcoholic fatty liver disease prevalence in urban school-aged children and adolescents from the Yangtze River delta region: a cross-sectional study. Asia Pac J Clin Nutr 2015; 24: 281-288.
15. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006; 95: 1635-1641.
16. Cole TJ, Bellizzi CM, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. Br Med J 2000; 320: 1240.
17. Venkatesh SK, Hennedige T, Johnson GB, Hough DM, Fletcher JG. Imaging patterns and focal lesions in fatty liver: a pictorial review. Abdom Radiol (NY) 2016 Dec 20. [Epub ahead of print]
18. Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clin Nutr 2007; 26: 409-415.
19. Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics 2006; 118; 1388-1393.
20. Welsh JA, Karpen S, Vos MB. Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010. J Pediatr 2013; 162: 496-500.
21. Akcam M, Boyaci A, Pirgon O, Koroglu M, Dundar BN. Importance of the liver ultrasound scores in pubertal obese children with nonalcoholic fatty liver disease.SOYKÖSE- Clin Imaging 2013; 37: 504-508.
22. Reinehr T, Toschke AM. Onset of puberty and cardiovascular risk factors in untreated obese children and adolescents: a 1-year follow-up study. Arch Pediatr Adolesc Med 2009; 163: 709-715.
23. Eng K, Lopez R, Liccardo D, Nobili V, Alkhouri N. A non-invasive prediction model for non-alcoholic steatohepatitis in paediatric patients with non-alcoholic fatty liver disease. Dig Liver Dis 2014; 46: 1008-1013.
24. Maffeis C, Banzato C, Rigotti F, et al. Biochemical parameters and anthropometry predict NAFLD in obese children. J Pediatr Gastroenterol Nutr 2011; 53: 590-593.