Yibo WU, Zhibao LV, Yimin HUANG, Faling CHEN, Jiangbin LİU

Primary cutaneous lymphoma in children: A report of four cases

Primary cutaneous lymphoma (CL) is a malignant lymphoma presenting inthe skin. Primary CL is rare in children and difficult to clinically diagnose.We report four pediatric cases of primary CL with tumors in different bodyarea: case 1, on the face and left thigh; case 2, on the left side of the neck;case 3, on the left side of the back; and case 4, on the left buttock. Thefirst diagnoses of these children were rash, abscess, lymphadenitis, and fever,respectively in local hospitals. All 4 patients were diagnosed as primary CLby histopathologic examination in our hospital. Three patients (case 1, case2 and case 4) were treated with chemotherapy. The size of tumor and degreeof cutaneous lesion were alleviated after chemotherapy. Case 3 refused toreceive chemotherapy, and died. The cases indicated the importance of earlydiagnosis of primary CL to guide appropriate therapy.

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1. Moon HR, Lee WJ, Won CH, et al. Paediatric cutaneous lymphoma in Korea: A retrospective study at a single institution. J Eur Acad Dermatol Venereol 2014; 28: 1798-1804.
2. Bradford PT, Devesa SS, Anderson WF, Toro JR. Cutaneous lymphoma incidence patterns in the United States: A population-based study of 3884 cases. Blood 2009; 113: 5064-5073.
3. Dummer R, Asagoe K, Cozzio A, et al. Recent advances in cutaneous lymphomas. J Dermatol Sci 2007; 48: 157-167.
4. Park JH, Shin HT, Lee DY, et al. World Health Organization-European Organization for Research and Treatment of Cancer Classification of Cutaneous Lymphoma in Korea: A retrospective study at a single tertiary institution. J Am Acad Dermatol 2012; 67: 1200-1209.
5. Yasukawa K, Kato N, Kodama K, Hamasaka A, Hata H. The spectrum of cutaneous lymphomas in Japan: A study of 62 cases based on the World Health Organization Classification. J Cutan Pathol 2006; 33: 487-491.
6. Massone C, Cerroni L. Phenotypic variability in primary cutaneous anaplastic large T-cell lymphoma: A study on 35 patients. Am J Dermatopathol 2014; 36: 153- 157.
7. Papalas JA, Van Mater D, Wang E. Pyogenic variant of primary cutaneous anaplastic large-cell lymphoma: A lymphoproliferative disorder with a predilection for the immunocompromized and the young. Am J Dermatopathol 2010; 32: 821-827.
8. Lam J, Pope E. Pediatric pityriasis lichenoides and cutaneous T-cell lymphoma. Curr Opin Pediatr 2007; 19: 441-445.
9. Hughes CF, Newland K, McCormack C, Lade S, Prince HM. Mycosis fungoides and Sezary syndrome: Current challenges in assessment, management and prognostic markers. Australas J Dermatol 2016; 57: 182-191.
10. Cuker A. Current and emerging therapeutics for heparin-induced thrombocytopenia. Semin Thromb Hemost 2012; 38: 31-37.
11. Zackheim HS. Treatment of mycosis fungoides/Sezary syndrome: The University of California, San Francisco (UCSF) Approach. Int J Dermatol 2003; 42: 53-56.
12. Plaza JA, Feldman AL, Magro C. Cutaneous CD30- positive lymphoproliferative disorders with CD8 expression: A clinicopathologic study of 21 cases. J Cutan Pathol 2013; 40: 236-247.
13. Specht L, Dabaja B, Illidge T, Wilson LD, Hoppe RT; International Lymphoma Radiation Oncology Group. Modern radiation therapy for primary cutaneous lymphomas: Field and dose guidelines from the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys 2015; 92: 32-39.
14. Kikuchi Y, Kashii Y, Gunji Y, et al. Six-year-old girl with primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. Pediatr Int 2011; 53: 393-396.
15. Kempf W, Kazakov DV, Belousova IE, Mitteldorf C, Kerl K. Paediatric cutaneous lymphomas: A review and comparison with adult counterparts. J Eur Acad Dermatol Venereol 2015; 29: 1696-1709.