Erdal ÇOŞKUN, Selçuk GÖÇMEN, Özkan ÇELİKER, Duygu ÇELİKER, Murat KOCAOĞLU, Abdullah TOPÇU

Melanotic neuroectodermal tumor of infancy in the skull: a case report

Kocaoğlu M, Göçmen S, Çeliker Ö, Çeliker D, Topçu A, Coşkun E. Melanotic neuroectodermal tumor of infancy in the skull: a case report. Turk J Pediatr 2015; 57: 183-185.Melanotic neuroectodermal tumor of infancy (MNTI) is a rarely occurring neoplasm of neural crest origin, appearing in children during the first year of life. MNTI is a benign tumor but is nonetheless locally aggressive; it usually originates from the maxilla and the mandible. Recognition of the diagnostic features of MNTI is important, so that it may be differentiated from benign lesions (dermoid or epidermoid cysts, vascular lesions) as well as from malignant lesions such as small round cell tumors. We present a case of a 2-month-old infant who developed right retroauricular swelling with extension through the calvarium and into the central nervous system. The tumor was totally resected. Aggressive benign or malignant lesions of the calvarium may entail dural infiltration and brain involvement, as in our case. Early diagnosis and surgery are thus mandatory for benign or malignant tumors of the calvarium.

PDF

___

1. Haque S, McCarville MB, Sebire N, McHugh K. Melanotic neuroectodermal tumour of infancy: CT and MR findings. Pediatr Radiol 2012; 42: 699-705.
2. Nazira B, Gupta H, Chaturvedi AK, Rao SA, Jena A. Melanotic neuroectodermal tumour of infancy: discussion of a case and a review of the imaging findings. Cancer Imaging 2009; 9: 121-125.
3. Selim H, Shaheen S, Barakat K, Selim AA. Melanotic neuroectodermal tumor of infancy: review of literature and case report. J Pediatr Surg 2008; 43: E25-E29.
4. Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J. Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case. Oral Surg Oral Med Oral Pathol Oral Rdiol Endod 2006; 102: 204-216.
5. Naidoo J, Potgieter L, Wieselthaler N, Pillay K. Melanotic neuroectodermal tumour of infancy, a rare cause for a bump on the head. Childs Nerv Syst 2013; 29: 167-172.
6. Gaiger de Oliveira M, Thompson LD, Chaves AC, Rados PV, da Silva Lauxen I, Filho MS. Management of melanotic neuroectodermal tumor of infancy. Ann Diagn Pathol 2004; 8: 207-212.
7. Antunes AC, Freitas RM, Oliveira PP, Rebouças RG. Melanotic neuroectodermal tumor of infancy: case report. Arq Neuropsiquiatr 2005; 63: 670-672.
8. Kantar M, Sezak M, Turhan T, et al. Melanotic progonoma of the skull in infancy. Childs Nerv Syst 2008; 24: 1371-1375.