A rare case of primary inoculation tuberculosis seen after varicella

Primary inoculation tuberculosis (TB) is a rare form of cutaneous TB resulting from direct introduction of Mycobacterium tuberculosis into the skin or mucosa of a previously uninfected, nonimmune person. We herein report the first case, to our knowledge, of primary inoculation TB to be seen after varicella; this case explains the possible mechanism of varicella-zoster virusmediated transient cellular immune suppression that predisposed the patient to cutaneous TB. In this case, we believe that varicella-zoster virus (VZV) infection predisposed the patient to primary inoculation TB by leading to direct inoculation of tuberculosis bacilli through vesicles or by suppressing cellular immunity.

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1. MacGregor RR. Cutaneous tuberculosis. Clin Dermatol 1995; 13: 245-255.

2. Morelli JG. Other cutaneous bacterial infections. In: Kliegman RM, Stanton BF, St. Geme JW III, Schor NF, Behrman RE (eds). Nelson Textbook of Pediatrics (19th ed). Philadelphia: Saunders Elsevier; 2011: 2304-2308.

3. Bravo FG, Gotuzzo E. Cutaneous tuberculosis. Clin Dermatol 2007; 25: 173-180.

4. Cohen JI. Infection of cells with varicella-zoster virus down-regulates surface expression of class I major histocompatibility complex antigens. J Infect Dis 1998; 177: 1390-1393.

5. Abendroth A, Slobedman B, Lee E, Mellins E, Wallace M, Arvin AM. Modulation of major histocompatibility class II protein expression by varicella-zoster virus. J Virol 2000; 74: 1900-1907.

6. Lisse IM, Qureshi K, Poulsen A, et al. T-lymphocyte subsets and eosinophil counts in acute and convalescence chickenpox infection: a household study in GuineaBissau. J Infect 2005; 50: 125-129.

7. Arneborn P, Biberfeld G. T-lymphocyte subpopulations in relation to immunosuppression in measles and varicella. Infect Immun 1983; 39: 29-37.

8. Cho S, Mehra V, Thoma-Uszynski S, et al. Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis. Proc Natl Acad Sci USA 2000; 97: 12210-12215.

9. Handog EB, Gabriel TG, Pineda RT. Management of cutaneous tuberculosis. Dermatol Ther 2008; 21: 154- 161.

10. Mataix J, Botella R, Herrero A, Lucas A. Tuberculous primary complex of the skin. Int J Dermatol 2008; 47: 479-481.
Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
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