Sinem AKGÜL, Ayşegül ÖZ, Kader KARLI OGUZ, Nuray KANBUR, Orhan DERMAN

Is white matter affected in adolescents with anorexia nervosa? A study using magnetization transfer imaging

SUMMARY: Akgül S, Öz A, Karlı-Oğuz K, Kanbur N, Derman O. Is white matter affected in adolescents with anorexia nervosa? A study using magnetization transfer imaging. Turk J Pediatr 2016; 58: 282-286. The aim of the study was to assess potential changes in structural integrity of the brain in adolescent patients with Anorexia Nervosa (AN) using the magnetization transfer imaging technique and re-evaluating after nutritional rehabilitation was accomplished. Magnetization transfer ratio (MTR) was used for the detection and quantification of histological changes to the white matter of 9 adolescents diagnosed with AN at diagnosis and after weight gain. Using the MTR technique 6 regions were measured: the pons, left cerebellar hemisphere, amygdala, thalamus, corona radiata and white matter adjacent to the left dorsolateral prefrontal cortex. Scans from the patients with AN were also compared with scans from an age-matched subset of 9 healthy controls. Compared with control subjects, the MTR of participants with AN was no different either at the early stages of diagnosis (p=0.62) or after weight recovery (p=0.81). Similarly, comparison of MTR between patients with AN at diagnoses compared with MTR after weight recovery yielded no statistically significant difference (P=0.33). We conclude that MTR was not able to detect any neuropathological alterations in adolescent patients with AN at either diagnosis or after nutritional recovery and the achievement of weight gain.

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1. Jáuregui-Lobera I. Neuroimaging in eating disorders. Neuropsychiatr Dis Treat 2011; 7: 577-584.

2. Chui HT, Christensen BK, Zipursky RB, et al. Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa. Pediatrics 2008; 122: 426-437.

3. King JA, Geisler D, Ritschel F, et al. Global cortical thinning in acute anorexia nervosa normalizes following long-term weight restoration. Biol Psychiatry 2015; 77: 624-632.

4. Katzman DK, Zipursky RB, Lambe EK, Mikulis DJ. A longitudinal magnetic resonance imaging study of brain changes in adolescents with anorexia nervosa. Arch Pediatr Adolesc Med 1997; 151: 793-797.

5. Grossman RI, Gomori JM, Ramer KN, et al. Magnetization transfer: theory and clinical applications in neuroradiology. Radiographics 1994; 14: 279-290.

6. Van Buchem M, Tofts PS. Magnetization transfer imaging. Neuroimaging Clin N Am 2000; 10: 771-788.

7. Filippi M, Campi A, Dousset V, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995; 45: 478-482.

8. Van der Voorn JP, Pouwels PJ, Salomons GS, Barkhof F, van der Knaap MS. Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter. Neuroradiology 2009; 51: 669-675.

9. Bagley LJ, McGowan JC, Grossman RI, et al. Magnetization transfer imaging of traumatic brain injury. J Magn Reson Imaging 2000; 11: 1-8.

10. Jurgens CK, Bos R, Luyendijk J, et al. Magnetization transfer imaging in ‘premanifest’Huntington’s disease. J Neurol 2010; 257: 426-432.

11. Ehrlich S, Burghardt R, Weiss D, et al. Glial and neuronal damage markers in patients with anorexia nervosa. J Neural Transm 2008; 115: 921-927.

12. Kraeft JJ, Uppot RN, Heffess AM. Imaging findings in eating disorders. AJR Am J Roentgenol 2013; 200: 328-335.

13. Giedd JN, Blumenthal J, Jeffries NO, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 1999; 2: 861- 863.

14. Arain M, Haque M, Johal L, et al. Maturation of the adolescent brain. Neuropsychiatr Dis Treat 2013; 9: 449-461.

15. Schwartz DH, Dickie E, Pangelinan MM, et al. Adiposity is associated with structural properties of the adolescent brain. Neuro Image 2014; 103: 192-201.

16. El Ghoch M, Calugi S, Lamburghini S, et al. Anorexia nervosa and body fat distribution: a systematic review. Nutrients 2014; 6: 3895-3912.

17. Golden NH, Ashtari M, Kohn MR, et al. Reversibility of cerebral ventricular enlargement in anorexia nervosa, demonstrated by quantitative magnetic resonance imaging. J Pediatr 1996; 128: 296-301.

18. Travis KE, Golden NH, Feldman HM et al. Abnormal white matter properties in adolescent girls with anorexia nervosa. Neuroimage Clin 2015; 9: 648-659.

19. Yau WY, Bischoff-Grethe A, Theilmann RJ, et al.Alterations in white matter microstructure in women recovered from anorexianervosa. Int J Eat Disord 2013; 46: 701-708.