Karadaş U, Eliaçık K, Baran M, Kanık A, Özdemir N, İnce OT, Bakiler AR. The subclinical effect of celiac disease on the heart and the effect of gluten-free diet on cardiac functions. Turk J Pediatr 2016; 58: 241-245.This study aimed to investigate the effects of celiac disease (CD) on cardiac function in children by using conventional transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Forty-nine patients diagnosed with CD were enrolled into the study. Group 1 consisted of 26 (53%) patients who had recently been diagnosed and had not been on glutenfree diet whereas Group 2 consisted of 23 (47%) patients who had been on regular gluten-free diet for at least 10 months. 20 healthy children were enrolled into the study as the control group. The deceleration time (DT) and the left ventricle (LV) isovolumetric relaxation time (IVRT) were significantly shorter in Group 1 compared to Group 2 and the control group (p=0.002, p=0.015). Mitral valve E/E' ratio was significantly lower in Group 1 and 2 when compared to the control group (p<0.001). The study demonstrated that evaluation of these parameters by using TDE could be beneficial in the early diagnosis of cardiac involvement in children with CD.
___
1. Sollid LM, McAdam SN, Molberg O, et al. Genes and environment in celiac disease. Acta Odontol Scand 2001; 59: 183-186.
2. Not T, Faleschini E, Tommasini A,et al. Celiac disease in patient with sporadic and inherited cardiomyopathies and in their relatives. Eur Heart J 2003; 24: 1455-1461.
3. Saylan B, Cevik A, Kirsaclioglu CT, Ekici F, Tosun O, Ustundag G. Subclinical cardiac dysfunction in children with coeliac disease: is the gluten-free diet effective? ISRN Gastroenterol 2012; 2012: 706937.
4. Lionetti E, Catassi C, Francavilla R, et al. Subclinic cardiac involvement in paediatric patients with celiac disease: a novel sign for a case finding approach. J Biol Regul Homeost Agents 2012; 26: 63-68.
5. Vinereanu D, Ionescu AA, Fraser AG. Assessment of left ventricular long axis contraction can detect early myocardial dysfunction in asymptomatic patients with severe aortic regurgitation. Heart 2001; 85: 30-36.
6. Tassan-Mangina S, Brasselet C, Nazeyrollas P, et al. Value of pulsed Doppler tissue imaging for early detection of myocardial dysfunction with anthracyclines. Arch Mal Coeur Vaiss 2002; 95: 263-268.
7. Flachskampf FA, Breithardt OA, and Daniel WG. Diagnostic value of tissue Doppler parameters in the early diagnosis of cardiomyopathies. Herz 2007; 32: 89-96.
8. Dandel M, Hummel M, Müller J, et al. Reliability of tissue Doppler wall motion monitoring after heart transplantation for replacement of invasive routine screenings by optimally timed cardiac biopsies and catheterizations. Circulation 2001; 104: 184-191.
9. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002; 346: 180-188.
10. Polat TB, Urganci N, Yalcin Y, et al. Cardiac functions in children with coeliac disease during follow-up: insights from tissue Doppler imaging. Dig Liver Dis 2008; 40: 182-187.
11. Husby S, Koletzko S, Korponay-Szabo´ IR, et al. European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for the diagnosis of coeliac disease. ESPGHAN Working Group on Coeliac Disease Diagnosis, on behalf of the ESPGHAN Gastroenterology Committee. JPGN 2012; 54: 572.
12. Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 2010; 23: 685-713.
13. Teichholz LE, Cohen MV, Sonnenblick EH, Gorlin R. Study of left ventricular geometry and function by B scan ultrasonography in patients with and without asynergy. N Engl J Med 1974; 291: 1220-1226.
14. Van Elburg RM, Uil JJ, Mulder CJ, Heymans HS. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 1993; 34: 354-357.
15. DeMeo MT, Mutlu EA, Keshavarzian A, Tobin MC. Intestinal permeation and gastrointestinal disease. J Clin Gastroenterol 2002; 34: 385-396.
16. Curione M, Barbato M, Viola F, Francia P, De Biase L, Cuchiara S. Idiopathic dilated cardiomyopathy associated with coeliac disease: the effect of a glutenfree diet on cardiac performance. Dig Liver Dis 2002; 34: 866-869.
17. Bardella MT, Fraquelli M, Quatrini M, Molteni N, Bianchi P, Conte D. Prevalence of hypertransaminasemia in adult patients an effect of gluten-free diet. Hepatology 1995; 22: 833-836.
18. Sari C, Bayram NA, Doğan FE, et al. The evaluation of endothelial functions in patients with celiac disease. Echocardiography 2012; 29: 471-477.
19. Armstrong WF, Ryan Thomas. Feigenbaum Ekokardiyografi. Sol ventrikül diyastolik fonksiyonlarının değerlendirilmesi (Çev: Gölbaşı Z). Ankara: Güneş Tıp Kitabevleri; 2011: 159-183.
20. Chicco D, Taddio A, Sinagra G, et al. Speeding up coeliac disease diagnosis in cardiological settings. Arch Med Sci 2010; 6: 728-732.