Decreased bone ultrasound velocity in premature infants conceived with assisted reproduction

Decreased bone ultrasound velocity in premature infants conceived with assisted reproduction

Armangil D, Gürsoy T, Korkmaz A, Özyüncü Ö. Decreased bone ultrasound velocity in premature infants conceived with assisted reproduction. Turk J Pediatr 2015; 57: 17-25.Quantitative ultrasound (QUS) measurement of tibial speed of sound (SOS) can be used to determine bone strength. Children conceived with assisted reproduction treatments (ART) are taller than naturally conceived (NC) children, so we hypothesized that these infants would have higher SOS levels than NC infants. Thirty-seven ART (ART group) and 51 NC neonates (NC group) were included in the study. Tibial initial SOS (iSOS) was measured within 96 hours of birth using QUS. Measurements were performed weekly until the infant was discharged from the hospital. The iSOS levels of the ART group (2823.41±110.8 m/sec) were lower than those of the NC group (2917.14±145.6 m/sec) (p=0.001). A decrease in SOS levels was observed in 39 of 53 infants who had serial scans. The difference in SOS levels between the first and last scan was significant (p

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  • Koo WWK, Steichen JJ. Osteopenia and rickets of prematurity. In: Polin R, Fox W (eds). Fetal and Neonatal Physiology (2nd ed). Philadelphia: W. B. Saunders; 1998: 2335-2349.
  • Ziegler EE, O’Donnell AM, Nelson SE, Fomon SJ. Body composition of the reference fetus. Growth 1976; 40: 329-341.
  • Litmanovitz I, Dolfin T, Friedland O, et al. Early physical activity intervention prevents decrease of bone strength in very low birth weight infants. Pediatrics 2003; 112: 15-19.
  • McDevitt H, Tomlinson C, White MP, Ahmed SF. Quantitative ultrasound assessment of bone in preterm and term neonates. Arch Dis Child Fetal Neonatal Ed 2005; 90: F341-F342.
  • Backström MC, Kouri T, Kuusela AL, et al. Bone isoenzyme of serum alkaline phosphatase and serum inorganic phosphate in metabolic bone disease of prematurity. Acta Paediatr 2000; 89: 867-873.
  • Cortet B, Boutry N, Dubois P, Legroux-Gérot I, Cotten A, Marchandise X. Does quantitative ultrasound of bone reflect more bone mineral density than bone microarchitecture? Calcif Tissue Int 2004; 74: 60-67.
  • Prins SH, Jİrgensen HL, Jİrgensen LV, Hassager C. The role of quantitative ultrasound in the assessment of bone: a review. Clin Physiol 1998; 18: 3-17.
  • Prevrhal S, Fuerst T, Fan B, et al. Quantitative ultrasound of the tibia depends on both cortical density and thickness. Osteoporos Int 2001; 12: 28-34.
  • Litmanovitz I, Dolfin T, Regev R, et al. Bone turnover markers and bone strength during the first weeks of life in very low birth weight premature infants. J Perinat Med 2004; 32: 58-61.
  • Nemet D, Dolfin T, Wolach B, Eliakim A. Quantitative ultrasound measurements of bone speed of sound in premature infants. Eur J Pediatr 2001; 160: 736-740.
  • Gursoy T, Yurdakok M, Hayran M, Korkmaz A, Yigit S, Tekinalp G. Bone speed of sound curves of twin and singleton neonates. J Pediatr Endocrinol Metab 2008; 21: 1065-1071.
  • Littner Y, Mandel D, Mimouni FB, Dollberg S. Bone ultrasound velocity curves of newly born term and preterm infants. J Pediatr Endocrinol Metab 2003; 16: 43-47.
  • Ritschl E, Wehmeijer K, de Terlizzi F, et al. Assessment of skeletal development in preterm and term infants by quantitative ultrasound. Pediatr Res 2005; 58: 341- 346.
  • Rubinacci A, Moro GE, Boehm G, de Terlizzi F, Moro GL, Cadossi R. Quantitative ultrasound for the assessment of osteopenia in preterm infants. Eur J Endocrinol 2003; 149: 307-315.
  • Miles HL, Hofman PL, Peek J, et al. In vitro fertilization improves childhood growth and metabolism. J Clin Endocrinol Metab 2007; 92: 3441-3445.
  • Ballard JL, Novak KK, Driver M. A simplified score for assessment of fetal maturation of newly born infants. J Pediatr 1979; 95: 769-774.
  • Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 2004; 328: 261.
  • Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 2004; 103: 551-563.
  • McDonald SD, Murphy K, Beyene J, Ohlsson A. Perinatal outcomes of singleton pregnancies achieved by in vitro fertilization: a systematic review and meta- analysis. J Obstet Gynaecol Can 2005; 27: 449-459.
  • Young LE, Fernandes K, McEvoy TG, et al. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat Genet 2001; 27: 153- 154.
  • Makhoul IR, Tamir A, Bader D, et al. In vitro fertilisation and use of ovulation enhancers may both influence childhood height in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 2009; 94: F355-F359.
  • Gertner JM. Disorders of calcium and phosphorus homeostasis. Pediatr Clin North Am 1990; 37: 1441– 1465.
  • Miller ME. The bone disease of preterm birth: a biomechanical perspective. Pediatr Res 2003; 53: 10–15.
  • Pereda L, Ashmeade T, Zaritt J, Carver JD. The use of quantitative ultrasound in assessing bone status in newborn preterm infants. J Perinatol 2003; 23: 655- 659.
  • Ryan S. Bone mineralization in preterm infants. Nutrition 1998: 14: 745-747.
  • Roberts CT, Owens JA, Sferruzzi-Perri AN. Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth: lessons from mice and guinea pigs. Placenta 2008; 29: S42–S47.
  • Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Growth and development of children born after in vitro fertilization. Fertil Steril 2008; 90: 1662-1673.
  • Rojas-Marcos PM, David R, Kohn B. Hormonal effects in infants conceived by assisted reproductive technology. Pediatrics 2005; 116: 190–194.
  • Lanyon LE. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone 1996; 18: S37–S43.
  • Rodan GA. Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption. J Bone Miner Res 1991; 6: 527–530.
  • Reik W, Constância M, Fowden A, et al. Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J Physiol 2003; 547: 35-44.
  • Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001; 293: 1089- 1093.
  • Maher ER. Imprinting and assisted reproductive technology. Hum Mol Genet 2005; 14: R133-R138.
  • Ludwig M, Katalinic A, Gross S, Sutcliffe A, Varon R, Horsthemke B. Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J Med Genet 2005; 42: 289-291.
  • Webb AR. Who, what, where and when—influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol 2006; 92: 17-25.
  • Dror DK, Allen LH. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev 2010; 68: 465-477.
  • Namgung R, Mimouni F, Campaigne BN, Ho ML, Tsang RC. Low bone mineral content in summer- born compared with winter-born infants. J Pediatr Gastroenterol Nutr 1992; 15: 285-288.
  • Namgung R, Tsang RC, Specker BL, Sierra RI, Ho ML. Reduced serum osteocalcin and 1,25-dihydroxyvitamin D concentrations and low bone mineral content in small for gestational age infants: evidence of decreased bone formation rates. J Pediatr 1993; 122: 269-275.
  • Lifting the veil: reform vs tradition in Turkey—an interview with Nilofer Gole. Manushi 1997; 100: 7-12.
  • Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int 2006; 17: 1133-1140.
  • Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 1995; 61: S638-S645.
  • Grover SR, Morley R. Vitamin D deficiency in veiled or dark-skinned pregnant women. Med J Aust 2001; 175: 251-252.
  • Genuis SJ, Schwalfenberg GK, Hiltz MN, Vaselenak SA. Vitamin D status of clinical practice populations at higher latitudes: analysis and applications. Int J Environ Res Public Health 2009; 6: 151-173.
  • Callenbach JC, Sheehan MB, Abramson SJ, Hall RT. Etiologic factor in rickets of very low-birth-weight infants. J Pediatr 1981; 98: 800-805.
  • Rauch F, Schoenau E. The developing bone: slave or master of its cells and molecules? Pediatr Res 2001; 50: 309-314.
  • American Academy of Pediatrics Committee on Nutrition. Nutritional needs of low-birth-weight infants. Pediatrics 1985; 75: 976-989.
  • McDevitt H, Tomlinson C, White MP, Ahmed SF. Changes in quantitative ultrasound in infants born at less than 32 weeks’ gestation over the first 2 years of life: influence of clinical and biochemical changes. Calcif Tissue Int 2007; 81: 263-269.
  • Ashmeade T, Pereda L, Chen M, Carver JD. Longitudinal measurements of bone status in preterm infants. J Pediatr Endocrinol Metab 2007; 20: 415-424.
  • Liao XP, Zhang WL, He J, Sun JH, Huang P. Bone measurements of infants in the first 3 months of life by quantitative ultrasound: the influence of gestational age, season, and postnatal age. Pediatr Radiol 2005; 35: 847-853.
  • Tomlinson C, McDevitt H, Ahmed SF, White MP. Longitudinal changes in bone health as assessed by the speed of sound in very low birth weight preterm infants. J Pediatr 2006; 148: 450-455.
  • Beyers N, Alheit B, Taljaard JF, Hall JM, Hough SF. High turnover osteopenia in preterm babies. Bone 1994; 15: 5-13.
  • Rauch F, Schoenau E. Changes in bone density during childhood and adolescence: an approach based on bone’s biological organization. J Bone Miner Res 2001; 16: 597-604.
Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
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