Z. Bengi SEMERCİ, Fatih ÜNAL

3557

An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder

An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder

The purpose of this study was to examine the efficacy and safety of fluoxetine for short-term and long-term treatment in children and adolescents with obsessive-compulsive disorder (OCD). Twenty-three children and adolescents (mean age 12.0, SD = 2.3) treated with fluoxetine for OCD with or without Gilles de la Tourette's syndrome were the subjects of this study. The design was an open-label trial for 20 weeks of fixed-dose fluoxetine (20 mg/day). OCD symptom severity was measured with the Maudsley OCD scale and with Clinical Global Impression Scale (CGI). All of the patients were followed-up after discontinuation of the drug for 24 months. Patients with OCD showed a significant decrease in the severity of their OCD symptoms according to Maudsley OCD scores (p < 0.001) and CGI scores (p < 0.001). Fluoxetine was generally well tolerated, and side effects were relatively mild. Ten patients (43.5%) with OCD who responded to fluoxetine relapsed in the follow-up period, but responded well to fluoxetine. These results indicate that fluoxetine is effective and safe for short-term and long-term treatment of OCD in children and adolescents
PDF

___

Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: 6
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Arşiv
Sayıdaki Diğer Makaleler

The role of heterotopic gastric mucosa with or without colonization of Helicobacter pylori upon the diverse symptomatology of Meckel's diverticulum in children.

Pelin OĞUZKURT, Beril TALİM, F. Cahit TANYEL, Nebil BÜYÜKPAMUKÇU, Melda ÇAĞLAR, M. Emin ŞENOCAK

A study of the prevalence of having fractures and the affecting factors in young male adults throughout chiidhood and adolescence

Cemil YILDIZ, Mustafa BAŞBOZKURT, A. Sabri ATESALP, Ö. Faruk TEKBAŞ, Mahir GÜLEÇ, Metin HASDE

Fiberoptic phototherapy versus conventional daylight phototherapy for hyperbilirubinemia of term newborn

S. Ümit SARICI, M. Ruşen DÜNDARÖZ, Faruk ALPAY, Okan ÖZCAN, Erdal GÖKÇAY

Prenatal echocardiographic diagnosis of situs inversus totalis and transposition of the great arteries: A case report

Funda ÖZTUNÇ, Halil TÜRKOĞLU, İ. Levent SALTIK, Resmiye BEŞİKÇİ

Severe hemolytic anemia after repair of primum septal defect and cleft mitral valve

Dursun ALEHAN, Rıza DOĞAN, Huda ELSHERSHARI, Süheyla ÖZKUTLU, Fatma GÜMRÜK

Familial arthropathy with camptodactyly: Reports of two families

Alper SOYLU, Salih KAVUKÇU, Mehmet TÜRKMEN, Erdener ÖZER, Tülay CANDA

A case of Sandifer's syndrome with hand tremor

Ercan DEMİR, Sabiha AYSUN, Esin SAKA

An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder

Z. Bengi SEMERCİ, Fatih ÜNAL

Giant cell pneumonia in a leukemic child in remission: A case report

Ali BAYKAN, Güler KANRA, Zuhal AKÇÖREN, Melda ÇAĞLAR, A. Bülent CENGİZ, Ateş KARA, İlker ÇETİN

Familial microtia in four generations with variable expressivity and incomplete penetrance in association with type I syndactyly

Sevim BALCI, Sefa KAYA, Koray BODUROĞLU